Results 141 to 150 of about 6,479,069 (356)

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

A systematic approach for component-based software development [PDF]

, 2000
Component-based software development enables the construction of software artefacts by assembling prefabricated, configurable and independently evolving building blocks, called software components.
Ferreira Pires, L., Guareis de Farias, C.R., Sinderen, M.J. van   +2 more
core   +3 more sources

Software-Defined Value Stream Process Systems

Machines
The increasing volatility of the markets and the growing demand for customized products are challenges for future production to ensure maximum flexibility and adaptability.
Max Goebels, Alexander Schulte, Patrick Georgi, Fabian Heimberger, Jannik Schwalm, Oliver Liewerenz, Adrian Schäfer, Jürgen Fleischer, Alexander Verl, Hans-Christian Möhring, Volker Schulze, Sven Matthiesen, Nejila Parspour   +12 more
doaj   +1 more source

Factors Models of Scrum Adoption in the Software Development Process: A Systematic Literature Review [PDF]

ReCIBE, 2018
(Background) The adoption of Agile Software Development (ASD), in particular Scrum, has grown significantly since its introduction in 2001. However, in Lima, many ASDs implementations have been not suitable (uncompleted or inconsistent), thus losing ...
Marilyn Sihuay, Abraham Dávila, Marcelo Pessoa   +2 more
doaj  

Position paper: International workshop on the software process and software environments [PDF]

, 1986
Mark Dowson
openalex   +1 more source

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source

Thermal food processing computation software [PDF]

, 2011
The objective of this research consisted of developing the two following thermal food processing software: “F-CALC” is software developed to carry out thermal process calculations based on the well-known Ball's formula method, and “OPT-PROx” is software ...
Abakarov, Alik
core   +2 more sources

Experimental verification and validation of the SICN-oriented process mining algorithm and system

Journal of King Saud University: Computer and Information Sciences, 2022
The purpose of this paper is to verify the functional correctness of a specific process mining algorithm and to validate the requirement satisfaction of the targeted algorithm, as well.
Kyoung-Sook Kim, Dinh-Lam Pham, Young-In Park, Kwanghoon Pio Kim   +3 more
doaj  

Use of a common software system for collaborative clinical research on attentional processes in schizophrenia and ADHD [PDF]

, 1989
James M. Swanson, Keith H. Nuechterlein, Robert F. Asarnow, Eric Taylor, Robert Hunt, Rennet Shaywitz, Sally E. Shaywitz, Steven G. Potkin, Terry Early, C. Robert Cloninger, Michael I. Posner   +10 more
openalex   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source