Results 71 to 80 of about 713,154 (305)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

New Advances in the Machining of Hard Metals using Physics-Based Modeling

Engineering Transactions, 2014
The machining of hard metals historically has been understood to be challenging and costly due to its material properties (such as titanium’s low thermal conductivity and high hardness, and nickel’s rapid work-hardening and high strength at elevated ...
Troy D. MARUSICH, Shuji USUI, Luis ZAMORANO, Kerry MARUSICH, Juergen LEOPOLD   +4 more
doaj   +1 more source

Integrating Dynamic Models for CMM-Based Software Process Improvement [PDF]

, 2002
During the last decade software process simulation has been used to address a wide diversity of management problems. Some of these problems are related to strategic management, technology adoption, understanding, training and learning, and risk ...
Toro Bonilla, Miguel, Mercedes Ruiz, Miguel Toro, Isabel Ramos, Ramos Román, Isabel, Ruiz Carreira, Mercedes   +5 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Relevant Organizational Values in the Implementation of Software Process Improvement Initiatives

CLEI Electronic Journal, 2013
In a globalized world, organizational culture plays an important role in companies since it represents one of the main factors of business success in competitive scenarios.
Odette Mestrinho Passos, Arilo Claudio Dias-Neto, Raimundo da Silva Barreto   +2 more
doaj   +1 more source

Organizational Change Perspectives on Software Process Improvement [PDF]

Many software organizations have engaged in Software Process Improvement (SPI) and experienced the challenges related to managing such complex organizational change efforts.
Balshøj, Hans Henrik, Müller, Sune Dueholm, Mathiassen, Lars   +2 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Maximizing the value of the software development process by game theoretic analysis [PDF]

, 2010
In this paper, we introduce the novel approach of employing the economic mechanism design concept in the software development process, and investigate methods to create and adjust the incentives and disincentives of the process and align them with the ...
O'Connor, Rory, O'Connor, Rory V., Yilmaz, Murat, O\u27Connor, Rory, Rory V. O'Connor, Murat Yilmaz, Murat Yilmaz (58709), Rory V. O'Connor (12588769)   +7 more
core   +1 more source