Results 81 to 90 of about 1,924,275 (351)
Molecular Oncology, EarlyView.The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld +7 more
wiley +1 more source
Integrating automated support for a software management cycle into the TAME system [PDF]
, 1989 Software managers are interested in the quantitative management of software quality, cost and progress. An integrated software management methodology, which can be applied throughout the software life cycle for any number purposes, is required. The TAME (
Basili, Victor R., Sunazuka, Toshihiko
core +1 more source
Molecular Oncology, EarlyView.This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad +13 more
wiley +1 more source
Achieving higher capability maturity in construction process improvement [PDF]
Process improvement has been identified as one of the potential mechanisms to achieve the desired performance improvements within the UK construction industry.
Amaratunga, Dilanthi +2 more
core
The Dynamics of Creativity in Software Development
, 2013 Software is primarily developed for people by people and human factors must be studied in all software engineering phases. Creativity is the source to improvise solutions to problems for dominating complex systems such as software development.
Graziotin, Daniel
core +2 more sources
Non-functional Requirements Documentation in Agile Software Development: Challenges and Solution Proposal [PDF]
, 2017 Non-functional requirements (NFRs) are determinant for the success of software projects. However,they are characterized as hard to define, and in agile software development(ASD), are often given less priority and usually not documented. In this paper, we
Behutiye, Woubshet +4 more
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Molecular Oncology, EarlyView.Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran +16 more
wiley +1 more source
Evidence-Based Quality-Aware Agile Software Development Process: Design and Evaluation
IEEE AccessAgile software development (ASD) aims to deliver high-quality software. However, software quality often receives less attention in ASD due to focus on functionality.
Pertti Karhapaa +11 more
doaj +1 more source
Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer
Molecular Oncology, EarlyView.This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu +7 more
wiley +1 more source