Results 111 to 120 of about 4,881,863 (349)

A framework of critical success factors of cloud based project management software adoption

open access: yesInternational Journal of Information Systems and Project Management
Project Management (PM) software is an enabler of project success and is now being offered as a cloud-based software with the advancement of cloud computing.
L. I. Assalaarachchi   +2 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Automated support for experience-based software management [PDF]

open access: yes
To effectively manage a software development project, the software manager must have access to key information concerning a project's status. This information includes not only data relating to the project of interest, but also, the experience of past ...
Valett, Jon D.
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

A Generalized Method for Filtering Noise in Open-Source Project Selection

open access: yesInformation
GitHub hosts over 10 million repositories, providing researchers with vast opportunities to study diverse software engineering problems. However, as anyone can create a repository for any purpose at no cost, open-source platforms contain many non ...
Yi Ding, Qing Fang, Xiaoyan Liu
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

A Novel Framework for RDF Schema Extraction in NoSQL Databases Using Sentence-BERT

open access: yesIEEE Access
NoSQL databases, known for their flexibility and scalability, have become pivotal in handling diverse and unstructured data. However, their schema-less nature introduces significant challenges in metadata management, query optimization, and data ...
Saad Belefqih   +3 more
doaj   +1 more source

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