Results 61 to 70 of about 6,188,449 (296)

Modelling the emergent dynamics and major metabolites of the human colonic microbiota [PDF]

, 2015
Funded by Scottish Government's Rural and Environment Science and Analytical Services Division (RESAS) Acknowledgements We would like to thank Thanasis Vogogias, David Nutter and Alec Mann for their assistance in developing the software for this model ...
Aminov, Bagramyan, Barcenilla, Bratbak, Cotillard, David, Drake, Duncan, Duncan, Duncan, Duncan, Duncan, Duncan, Eckburg, Egert, Feijó Delgado, Filippo, Flint, Flint, Flint, Gottschalk, Kettle, Kovarova-Kovar, Latham, Liu, Lopez-Siles, Louis, Louis, Macfarlane, Marquet, Moore, Munoz-Tamayo, Nava, Norberg, Prins, Qin, Ragsdale, Reichardt, Richardson, Robert, Rogers, Russell, Salyers, Seeliger, Stephen, Swidsinski, Tap, Turnbaugh, Walker, Walker, Walker, Whitman, Wolin, Wu, Yachi, Ze   +55 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

AGCD: An Attention-Guided Graph Convolution Network for Change Detection of Remote Sensing Images

Remote Sensing
Change detection is a crucial field in remote sensing image analysis for tracking environmental dynamics. Although convolutional neural networks (CNNs) have made impressive strides in this field, their grid-based processing structures struggle to capture
Heng Li, Xin Lyu, Xin Li, Yiwei Fang, Zhennan Xu, Xinyuan Wang, Chengming Zhang, Chun Xu, Shaochuan Chen, Chengxin Lu   +9 more
doaj   +1 more source

Pembuatan Aplikasi Multimedia Untuk Membantu Siswa Sekolah Dasar Dalam Mempelajari Sains [PDF]

, 2010
Science is very important in our everyday lives. That is the reason why students have to learn science since the beginning of their primary school. However, many students find difficulties in studying science.
., Lisana
core  

A Boxology of Design Patterns for Hybrid Learning and Reasoning Systems [PDF]

, 2019
We propose a set of compositional design patterns to describe a large variety of systems that combine statistical techniques from machine learning with symbolic techniques from knowledge representation.
Teije, Annette ten, van Harmelen, Frank
core   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Software Engineering for Science

Computing in Science & Engineering, 2016
AEIC Jeffrey C. Carver describes ways to improve software engineering for science, introduces the Software Engineering Track for CiSE magazine, and provides a link to a survey that can inform future progress.
openaire   +3 more sources

Using entropy measures for comparison of software traces

, 2012
The analysis of execution paths (also known as software traces) collected from a given software product can help in a number of areas including software testing, software maintenance and program comprehension.
Davison, M., Miranskyy, A. V., Murtaza, S. S., Reesor, M.   +3 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source