Results 61 to 70 of about 7,470,706 (245)
A Decision Support System for Elective Surgery Scheduling under Uncertain Durations
The operation room (OR) is one of the most expensive material resources in hospitals. Additionally, the demand for surgical service is increasing due to the aging population, while the number of surgical interventions performed is stagnated because of ...
Daniel Clavel +3 more
doaj +1 more source
Characteristics and possibilities of software tool for metal-oxide surge arresters selection [PDF]
This paper presents a procedure for the selection of metal-oxide surge arresters based on the instructions given in the Siemens and ABB catalogues, respecting their differences and the characteristics and possibilities of the software tool.
Đorđević Dragan +2 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Stable and predictable Voronoi treemaps for software quality monitoring [PDF]
Context: Voronoi treemaps can be used to effectively visualize software quality attributes of a given software system. Algorithms for computing Voronoi treemaps are non-deterministic making them unsuited for monitoring the development of such attributes ...
Hage, J.; id_orcid +4 more
core +2 more sources
Structural and biochemical analysis of a B12 superbinder
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Virtual Simulation of Electric Bus Fleets for City Bus Transport Electrification Planning
City bus transport electrification has a strong potential of improving city air quality, reducing noise pollution and increasing passenger satisfaction.
Jakov Topić +4 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
A One-Stop Shop For Software Evolution Tool Construction
International audienceReal problems in software evolution render impossible a fixed, one-size-fits-all approach, and these problems are usually solved by gluing together various tools and languages. Such ad-hoc integration is cumbersome and costly.
Storm, T. (Tijs) van der +8 more
core

