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Sulfur fluoride exchange (SuFEx) is a powerful click platform, yet water‐compatible multifunctional linchpins remain elusive. Here, we report decagram‐scalable diazonium linchpins that enable rapid Pd‐catalyzed diversification and direct, catalyst‐free on‐DNA ligation in aqueous media.
Seok Ju Hong +5 more
wiley +1 more source
The Solid-Phase Synthesis of Complex Small Molecules
Jonathan A. Ellman
doaj +2 more sources
Efficient automated solid-phase synthesis of recognition-encoded melamine oligomers. [PDF]
Dhiman M, Cabot R, Hunter CA.
europepmc +1 more source
Synthesis and cyclization of modified prostate-specific antigen activating peptides using solid-phase peptide synthesis method [PDF]
Ekabe, Joel O
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Enantioselective Synthesis on the Solid Phase
ChemInform, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Leßmann, T., Waldmann, H.
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Solid phase synthesis of oligosaccharides
Tetrahedron Letters, 1996Abstract An efficient and stereocontrolled solid-phase chemical synthesis of oligosaccarides using a new type of insoluble support (a copolymer of polyethylene glycol and polystyrene) is described. Several Lewis acids were tested as activators of the trichloroacetimidate 12 , used as glycosyl donor, in the dimer 13 formation.
ADINOLFI M +4 more
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Solid phase synthesis of praziquantel
Tetrahedron Letters, 2006The first solid phase synthesis of the important anthelmintic praziquantel is described. The synthesis is rapid and efficient. The method may be extended to the synthesis of libraries of urgently needed replacements for this drug.
M. Todd, S. El-Fayyoumy, W. Mansour
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Solid Phase Synthesis of Oligosaccharides
2010Oligosaccharides are involved in many fundamental biological processes. However, relatively little is known about the precise molecular mechanism of action of these macromolecules, because the complexity of these structures impeded their synthesis by chemical methods analogous to those employed to create oligonucleotides and peptides.
Weishaupt, M., Eller, S., Seeberger, P.
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