Results 311 to 320 of about 1,857,199 (369)

Solid phase protein chemical synthesis.

Topics in current chemistry, 2015
The chemical synthesis of peptides or small proteins is often an important step in many research projects and has stimulated the development of numerous chemical methodologies. The aim of this review is to give a substantial overview of the solid phase methods developed for the production or purification of polypeptides.
L. Raibaut, O. El Mahdi, O. Melnyk
semanticscholar   +3 more sources

Solid‐Phase Synthesis

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
  +4 more sources

Advances in the Solid-Phase Synthesis of Pyrimidine Derivatives.

ACS Combinatorial Science, 2019
This Review describes the existing synthetic approaches for the solid-phase synthesis (SPS) of differently substituted and fused pyrimidine derivatives.
E. Aparna, K. Devaky
semanticscholar   +1 more source

Solid-phase phosphatidylethanolamine synthesis

Reactive Polymers, 1989
Abstract Dipalmitoylphosphatidylethanolamine(DPPE) was prepared from natural phosphatidylethanolamine (cephalin) and palmitic anhydride (PAh) by using polymer-supported trityl as a protective group for the ammo group of cephalin.
M. Tomoi, Y. Kimura, S. Tokuyama
openaire   +1 more source

Making Solid-Phase Peptide Synthesis Greener: A Review of the Literature.

Chemistry - An Asian Journal, 2019
To date, the synthesis of peptides is concurrent with the production of enormous amounts of toxic waste. DMF, CH2 Cl2 , and NMP are three of the most toxic organic solvents used in chemical synthesis and are the most common solvents used for peptide ...
Kyriakos G Varnava, V. Sarojini
semanticscholar   +1 more source

Green Transformation of Solid-Phase Peptide Synthesis

ACS Sustainable Chemistry and Engineering, 2019
Peptides play key roles in medicinal chemistry, being found in therapeutics and diagnostic agents, among others. Furthermore, their synthetic protocols have also been optimized for other fields such as the solid-phase organic synthesis of other organic ...
Yahya E. Jad, Ashish Kumar, A. El‐Faham, B. G. de la Torre, F. Albericio   +4 more
semanticscholar   +1 more source

Solid phase submonomer azapeptide synthesis

2021
Azapeptides contain at least one aza-amino acid, where the α-carbon has been replaced by a nitrogen atom, and have found broad applicability in fields ranging from medicinal chemistry to biomaterials. In this chapter, we provide a step-by-step protocol for the solid phase submonomer synthesis of azapeptides, which includes three steps: (1) hydrazone ...
Maxwell, Bowles, Caroline, Proulx
openaire   +2 more sources

Solid Phase Synthesis of Oligosaccharides

2010
Oligosaccharides are involved in many fundamental biological processes. However, relatively little is known about the precise molecular mechanism of action of these macromolecules, because the complexity of these structures impeded their synthesis by chemical methods analogous to those employed to create oligonucleotides and peptides.
Weishaupt, M., Eller, S., Seeberger, P.
openaire   +3 more sources

Solid-Phase Organometallic Synthesis

Chemistry - A European Journal, 2001
A solid-phase synthesis approach for a class of molybdenum carbonyl complexes has been developed. The system can be used to perform metal-complexation, ligand substitution reactions and oxidative eliminations on the solid phase and to cleave the final complexes under mild and selective conditions.
openaire   +2 more sources

Solid phase synthesis of quinolones

Bioorganic & Medicinal Chemistry Letters, 1999
Solid phase syntheses of ethyl 6-carboxyquinol-4(1H-)-one-3-carboxylate (5) and N-substituted 6-carboxyquinol-4(1H)-one-3-carboxamides 7a-d have been described. Antifilarial in vitro activities of 5,7a-d against Brugia malayi have also been delineated.
S K, Srivastava, W, Haq, P K, Murthy, P M, Chauhan   +3 more
openaire   +2 more sources