Results 1 to 10 of about 627,325 (311)

Epimerisation in Peptide Synthesis [PDF]

Molecules, 2023
Epimerisation is basically a chemical conversion that includes the transformation of an epimer into another epimer or its chiral partner. Epimerisation of amino acid is a side reaction that sometimes happens during peptide synthesis. It became the most avoided reaction because the process affects the overall conformation of the molecule, eventually ...
Muhamad İmam Muhajir, Ace Tatang Hidayat, Rani Maharani   +2 more
exaly   +5 more sources

Total wash elimination for solid phase peptide synthesis. [PDF]

Nat Commun, 2023
We present a process for solid phase peptide synthesis (SPPS) that completely eliminates all solvent intensive washing steps during each amino acid addition cycle.
Collins JM, Singh SK, White TA, Cesta DJ, Simpson CL, Tubb LJ, Houser CL.   +6 more
europepmc   +2 more sources

Acid-Modulated Peptide Synthesis for Application on Oxide Biosensor Interfaces. [PDF]

Nanomaterials (Basel), 2023
In this paper we report an acid-modulated strategy for novel peptide microarray production on biosensor interfaces. We initially selected a controlled pore glass (CPG) as a support for solid-phase peptide synthesis (SPPS) to implement a chemistry that ...
Cristóbal-Lecina E, El-Maiss J, Figueras E, Singh AC, Krishnamoorthy S, Østerbye T, Pascual García C, Andreu D.   +7 more
europepmc   +2 more sources

Peptide Synthesis

Bio-Protocol, 2012
This protocol describes the synthesis of peptides for affinity testing and bioconjugate with solid phase peptide synthesizer at a small scale.
zheng miao, Zhen Cheng
doaj   +2 more sources

Conjugation of amiodarone to a novel cardiomyocyte cell penetrating peptide for potential targeted delivery to the heart

Frontiers in Chemistry, 2023
Modern medicine has developed a myriad of therapeutic drugs against a wide range of human diseases leading to increased life expectancy and better quality of life for millions of people.
Ray Yurko, Kazi Islam, Beth Weber, Guy Salama, Maliha Zahid   +4 more
doaj   +1 more source

A green protocol for the one-pot synthesis of 3,4-disubstituted isoxazole-5(4H)-ones using modified β-cyclodextrin as a catalyst

Scientific Reports, 2022
This manuscript reports an impressive and facile strategy for synthesizing isoxazole derivatives using immobilized Cu (I) in metformin-functionalized β-cyclodextrin as a catalyst.
Mahdieh Tajbakhsh, Mohammad Reza Naimi-Jamal, Saeed Balalaie, Mohadeseh Rezaeian   +3 more
doaj   +1 more source

Chimeric Peptides Derived from Bovine Lactoferricin and Buforin II: Antifungal Activity against Reference Strains and Clinical Isolates of Candida spp.

Antibiotics, 2022
Antimicrobial peptides (AMPs) are considered to be a valuable source for the identification and/or design of promising candidates for the development of antifungal treatments, since they have advantages such as lower tendency to induce resistance, ease ...
Katherine Aguirre-Guataqui, Mateo Márquez-Torres, Héctor Manuel Pineda-Castañeda, Yerly Vargas-Casanova, Andrés Ceballos-Garzon, Zuly Jenny Rivera-Monroy, Javier Eduardo García-Castañeda, Claudia Marcela Parra-Giraldo   +7 more
doaj   +1 more source

Peptides, solid-phase synthesis and characterization: Tailor-made methodologies

Electronic Journal of Biotechnology, 2023
Background: Solid-Phase Peptide Synthesis (SPPS) is a mature technique widely used in research and in production. There are different approaches that fulfill the diverse requirements, regarding the number, quantity and quality of peptides.
Fanny Guzmán, Mónica Aróstica, Tanya Román, Dina Beltrán, Adriana Gauna, Fernando Albericio, Constanza Cárdenas   +6 more
doaj   +1 more source

Heterologous Rhamnolipid Biosynthesis: Advantages, Challenges, and the Opportunity to Produce Tailor-Made Rhamnolipids

Frontiers in Bioengineering and Biotechnology, 2020
The first heterologous expression of genes responsible for the production of rhamnolipids was already implemented in the mid-1990s during the functional identification of the rhlAB operon.
Andreas Wittgens, Andreas Wittgens, Frank Rosenau, Frank Rosenau, Frank Rosenau   +4 more
doaj   +1 more source

Aza-peptides: expectations and reality [PDF]

Proceedings of the Estonian Academy of Sciences, 2022
The replacement of the α-carbon atom in an α-amino acid structure by a nitrogen atom yields alkylcarbazic acids, also known as α-aza amino acids.
Anu Ploom, Anton Mastitski, Meeli Arujõe, Alla Troska, Jaak Järv   +4 more
doaj   +1 more source