Results 21 to 30 of about 594,502 (265)
Realizing Serine/Threonine Ligation: Scope and Limitations and Mechanistic Implication Thereof
Frontiers in Chemistry, 2014 Serine/Threonine ligation (STL) has emerged as an alternative tool for protein chemical synthesis, bioconjugations as well as macrocyclization of peptides of various sizes. Owning to the high abundance of Ser/Thr residues in natural peptides and proteins,
Clarence T. T. Wong +10 more
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Introduction to Peptide Synthesis [PDF]
Current Protocols in Protein Science, 2012 AbstractA number of synthetic peptides are significant commercial or pharmaceutical products, ranging from the dipeptide sugar substitute aspartame to clinically used hormones such as oxytocin, adrenocorticotropic hormone, and calcitonin. This unit provides an overview of the field of synthetic peptides and proteins.
Maciej, Stawikowski, Gregg B, Fields
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Bio-Protocol, 2012 This protocol describes the synthesis of peptides for affinity testing and bioconjugate with solid phase peptide synthesizer at a small scale.
zheng miao, Zhen Cheng
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γ effects identify preferentially populated rotamers of CH2F groups: side-chain conformations of fluorinated valine analogues in a protein [PDF]
Magnetic ResonanceUsing cell-free protein synthesis, the protein G B1 domain (GB1) was prepared with uniform high-level substitution of valine by (2S,3S)-4-fluorovaline, (2S,3R)-4-fluorovaline or 4,4'-difluorovaline.
E. H. Abdelkader +4 more
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Nature, 1949 Cook, Heilbron and Levy1 have recently prepared tetraglycylglycine and several di-peptides by reaction of 2-thio-5-thiazolones with amino-acid derivatives. During the past few years, much interest has also been shown in the polymerization potentialities of the N-carboxy anhydrides of α-amino-acids2–5.
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Molecules, 2021 Addition of the silylated tag (STag) enables peptides to be highly soluble in CPME, allowing them to be used at high concentrations in a coupling reaction to enhance reactivity and achieve effective synthesis of sterically hindered peptides. We described
Shinya Yano +2 more
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Recyclable hypervalent-iodine-mediated solid-phase peptide synthesis and cyclic peptide synthesis
Beilstein Journal of Organic Chemistry, 2018 The system of the hypervalent iodine(III) reagent FPID and (4-MeOC6H4)3P was successfully applied to solid-phase peptide synthesis and cyclic peptide synthesis.
Dan Liu, Ya-Li Guo, Jin Qu, Chi Zhang
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Recent Advances and Trends in Chemical CPP–Drug Conjugation Techniques
Molecules, 2021 This review summarizes recent developments in conjugation techniques for the synthesis of cell-penetrating peptide (CPP)–drug conjugates targeting cancer cells.
Félix Gayraud +2 more
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A Rapid and Efficient Building Block Approach for Click Cyclization of Peptoids
Frontiers in Chemistry, 2020 Cyclic peptide-peptoid hybrids possess improved stability and selectivity over linear peptides and are thus better drug candidates. However, their synthesis is far from trivial and is usually difficult to automate.
Mamidi Samarasimhareddy +5 more
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Exploiting Conserved Quorum Sensing Signals in Streptococcus mutans and Streptococcus pneumoniae
Microorganisms, 2022 Bacterial species of the Streptococcus genera are considered either commensal bacteria or potential pathogens, according to their metabolic evolution and production of quorum sensing (QS)-controlled virulence factors. S. mutans, in particular, has become
Giulia Bernabè +6 more
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