Results 21 to 30 of about 3,503,980 (299)

Inter-residue through-space scalar ¹⁹F–¹⁹F couplings between CH₂F groups in a protein [PDF]

Magnetic Resonance
Using cell-free protein synthesis, the protein G B1 domain (GB1) was prepared with uniform high-level substitution of leucine by (2S,4S)-5-fluoroleucine (FLeu1), (2S,4R)-5-fluoroleucine (FLeu2), or 5,5′-difluoroleucine (diFLeu).
Y. J. Tan, E. H. Abdelkader, I. D. Herath, A. Maleckis, G. Otting   +4 more
doaj   +1 more source

Automated Peptide Synthesizers and Glycoprotein Synthesis

Frontiers in Chemistry, 2022
The development and application of commercially available automated peptide synthesizers has played an essential role in almost all areas of peptide and protein research.
Jiekang Tian, Yaohao Li, Bo Ma, Zhongping Tan, Shiying Shang   +4 more
doaj   +1 more source

Commercial manufacturing of current good manufacturing practice peptides spanning the gamut from neoantigen to commercial large-scale products

Medicine in Drug Discovery, 2021
Peptide therapeutics represents a significant and growing area for manufacturing companies utilizing both chemical and recombinant methods. Approvals for orally administered peptides such as Linzess® (linaclotide), Trulance® (plecanatide), and most ...
Michael W. Pennington, Brant Zell, Chris J. Bai   +2 more
doaj   +1 more source

Cardiomyocyte-Targeting Peptide to Deliver Amiodarone

Pharmaceutics, 2023
Background: Amiodarone is underutilized due to significant off-target toxicities. We hypothesized that targeted delivery to the heart would lead to the lowering of the dose by utilizing a cardiomyocyte-targeting peptide (CTP), a cell-penetrating peptide ...
Maliha Zahid, Beth Weber, Ray Yurko, Kazi Islam, Vaishavi Agrawal, Jack Lopuszynski, Hisato Yagi, Guy Salama   +7 more
doaj   +1 more source

The synthesis of an analogue of the locust CRF-like diuretic peptide, and the biological activities of this and some C-terminal fragments. [PDF]

, 2003
The synthesis is described of an analogue of the locust CRF-like diuretic peptide in which methionine in positions 1,3, and 13 is replaced by isosteric methyl-homoserine residues.
Simmonds, M.S.J., Poulos, C.P., Tatari, M., Goldsworthy, Graham J., Chung, J.S., Varouni, S.   +5 more
core   +1 more source

A deeper mining on the protein composition of VA-MENGOC-BC®: An OMV-based vaccine against N. meningitidis serogroup B and C

Human Vaccines & Immunotherapeutics, 2017
The protein composition of an Outer Membrane Vesicle (OMV) preparation that constitutes the active pharmaceutical ingredient of VA-MENGOC-BC®, an effective vaccine against Neisseria meningitidis serogroups B, and C is presented.
Yordanka Masforrol, Jeovanis Gil, Darien García, Jesús Noda, Yassel Ramos, Lázaro Betancourt, Osmany Guirola, Sonia González, Boris Acevedo, Vladimir Besada, Osvaldo Reyes, Luis Javier González   +11 more
doaj   +1 more source

Realizing Serine/Threonine Ligation: Scope and Limitations and Mechanistic Implication Thereof

Frontiers in Chemistry, 2014
Serine/Threonine ligation (STL) has emerged as an alternative tool for protein chemical synthesis, bioconjugations as well as macrocyclization of peptides of various sizes. Owning to the high abundance of Ser/Thr residues in natural peptides and proteins,
Clarence T. T. Wong, Clarence T. T. Wong, Tianlu eLi, Tianlu eLi, Hiu Yung eLam, Hiu Yung eLam, Yinfeng eZhang, Yinfeng eZhang, Xuechen eLI, Xuechen eLI, Xuechen eLI   +10 more
doaj   +1 more source

A New Peptide Synthesis [PDF]

Nature, 1949
Cook, Heilbron and Levy1 have recently prepared tetraglycylglycine and several di-peptides by reaction of 2-thio-5-thiazolones with amino-acid derivatives. During the past few years, much interest has also been shown in the polymerization potentialities of the N-carboxy anhydrides of α-amino-acids2–5.
openaire   +2 more sources

Peptide Synthesis

Bio-Protocol, 2012
This protocol describes the synthesis of peptides for affinity testing and bioconjugate with solid phase peptide synthesizer at a small scale.
zheng miao, Zhen Cheng
doaj   +1 more source

The use of chemically stabilised proteolytic enzymes in peptide synthesis [PDF]

, 2003
The aim of this project was to study various serine proteases, both native and chemically modified, with a view to their application in peptide synthesis.
Colleary, Sandra
core   +2 more sources