Results 21 to 30 of about 627,325 (311)

Inter-residue through-space scalar ¹⁹F–¹⁹F couplings between CH₂F groups in a protein [PDF]

Magnetic Resonance
Using cell-free protein synthesis, the protein G B1 domain (GB1) was prepared with uniform high-level substitution of leucine by (2S,4S)-5-fluoroleucine (FLeu1), (2S,4R)-5-fluoroleucine (FLeu2), or 5,5′-difluoroleucine (diFLeu).
Y. J. Tan, E. H. Abdelkader, I. D. Herath, A. Maleckis, G. Otting   +4 more
doaj   +1 more source

Automated Peptide Synthesizers and Glycoprotein Synthesis

Frontiers in Chemistry, 2022
The development and application of commercially available automated peptide synthesizers has played an essential role in almost all areas of peptide and protein research.
Jiekang Tian, Yaohao Li, Bo Ma, Zhongping Tan, Shiying Shang   +4 more
doaj   +1 more source

Transcription of brain natriuretic peptide and atrial natriuretic peptide genes in human tissues [PDF]

, 1994
We have compared the expression of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) genes in various human tissues using a quantitative polymerase chain reaction technique.
Nguyen, T., Nemer, M., Dagnino, Lina, Nemer, Mona, Nguyen, Than, Gerbes, Alexander L., Dagnino, L.   +6 more
core   +1 more source

Commercial manufacturing of current good manufacturing practice peptides spanning the gamut from neoantigen to commercial large-scale products

Medicine in Drug Discovery, 2021
Peptide therapeutics represents a significant and growing area for manufacturing companies utilizing both chemical and recombinant methods. Approvals for orally administered peptides such as Linzess® (linaclotide), Trulance® (plecanatide), and most ...
Michael W. Pennington, Brant Zell, Chris J. Bai   +2 more
doaj   +1 more source

Cardiomyocyte-Targeting Peptide to Deliver Amiodarone

Pharmaceutics, 2023
Background: Amiodarone is underutilized due to significant off-target toxicities. We hypothesized that targeted delivery to the heart would lead to the lowering of the dose by utilizing a cardiomyocyte-targeting peptide (CTP), a cell-penetrating peptide ...
Maliha Zahid, Beth Weber, Ray Yurko, Kazi Islam, Vaishavi Agrawal, Jack Lopuszynski, Hisato Yagi, Guy Salama   +7 more
doaj   +1 more source

A deeper mining on the protein composition of VA-MENGOC-BC®: An OMV-based vaccine against N. meningitidis serogroup B and C

Human Vaccines & Immunotherapeutics, 2017
The protein composition of an Outer Membrane Vesicle (OMV) preparation that constitutes the active pharmaceutical ingredient of VA-MENGOC-BC®, an effective vaccine against Neisseria meningitidis serogroups B, and C is presented.
Yordanka Masforrol, Jeovanis Gil, Darien García, Jesús Noda, Yassel Ramos, Lázaro Betancourt, Osmany Guirola, Sonia González, Boris Acevedo, Vladimir Besada, Osvaldo Reyes, Luis Javier González   +11 more
doaj   +1 more source

Realizing Serine/Threonine Ligation: Scope and Limitations and Mechanistic Implication Thereof

Frontiers in Chemistry, 2014
Serine/Threonine ligation (STL) has emerged as an alternative tool for protein chemical synthesis, bioconjugations as well as macrocyclization of peptides of various sizes. Owning to the high abundance of Ser/Thr residues in natural peptides and proteins,
Clarence T. T. Wong, Clarence T. T. Wong, Tianlu eLi, Tianlu eLi, Hiu Yung eLam, Hiu Yung eLam, Yinfeng eZhang, Yinfeng eZhang, Xuechen eLI, Xuechen eLI, Xuechen eLI   +10 more
doaj   +1 more source

γ effects identify preferentially populated rotamers of CH₂F groups: side-chain conformations of fluorinated valine analogues in a protein [PDF]

Magnetic Resonance
Using cell-free protein synthesis, the protein G B1 domain (GB1) was prepared with uniform high-level substitution of valine by (2S,3S)-4-fluorovaline, (2S,3R)-4-fluorovaline or 4,4'-difluorovaline.
E. H. Abdelkader, N. F. Chilton, N. F. Chilton, A. Maleckis, G. Otting   +4 more
doaj   +1 more source

Membrane-Active Peptides and Their Potential Biomedical Application

Pharmaceutics, 2023
Membrane-active peptides (MAPs) possess unique properties that make them valuable tools for studying membrane structure and function and promising candidates for therapeutic applications.
Andreea Gostaviceanu, Simona Gavrilaş, Lucian Copolovici, Dana Maria Copolovici   +3 more
doaj   +1 more source

Natriuretic peptide receptors regulate cytoprotective effects in an ex vivo human 3D/bioreactor model [PDF]

, 2013
IntroductionThe present study examined the effect of C-type natriuretic peptide (CNP) and biomechanical signals on anabolic and catabolic activities in chondrocyte/agarose constructs.MethodsNatriuretic peptide (Npr) 2 and 3 expression were compared in ...
Salter, Donald M, Salter, Donald M., Ramachandran, Manoj, Adrian J Hobbs, Hobbs, Adrian J., Ramachandran, M, Moyes, AJ, Amie J Moyes, Peake, Nicholas, Bader, Dan L, Bader, DL, Chowdhury, Tina T., Donald M Salter, Pramod Achan, Bader, Dan L., Peake, N, Su, N, Achan, P, Hobbs, AJ, Salter, DM, Nyan Su, Achan, Pramod, Nicholas Peake, Chowdhury, TT, Moyes, Amie J., Dan L Bader, Tina T Chowdhury, Su, Nyan, Chowdhury, Tina T, Hobbs, Adrian J, Moyes, Amie J, Manoj Ramachandran   +31 more
core   +1 more source