Results 41 to 50 of about 627,325 (311)

Influence of Disulfide Connectivity on Structure and Bioactivity of α-Conotoxin TxIA

Molecules, 2014
Cone snails express a sophisticated arsenal of small bioactive peptides known as conopeptides or conotoxins (CTxs). Through evolutionary selection, these peptides have gained the ability to interact with a range of ion channels and receptors, such as ...
Yong Wu, Xiaosa Wu, Jinpeng Yu, Xiaopeng Zhu, Dongting Zhangsun, Sulan Luo   +5 more
doaj   +1 more source

Biologic Evaluation of a Heterodimeric HER2-Albumin Targeted Affibody Molecule Produced by Chemo-Enzymatic Peptide Synthesis

Pharmaceutics, 2022
Targeted molecular radiation therapy is a promising emerging treatment modality in oncology, and peptide synthesis may shorten the time to reach the clinical stage.
Yongsheng Liu, Rezan Güler, Yunqi Liao, Anzhelika Vorobyeva, Olof Widmark, Theodorus J. Meuleman, Anna Koijen, Leendert J. van den Bos, Robert Naasz, Vitalina Bodenko, Anna Orlova, Caroline Ekblad, Vladimir Tolmachev, Fredrik Y. Frejd   +13 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

The synthesis of an analogue of the locust CRF-like diuretic peptide, and the biological activities of this and some C-terminal fragments.

, 2003
The synthesis is described of an analogue of the locust CRF-like diuretic peptide in which methionine in positions 1,3, and 13 is replaced by isosteric methyl-homoserine residues.
Simmonds, M.S.J., Poulos, C.P., Tatari, M., Goldsworthy, Graham J., Chung, J.S., Varouni, S.   +5 more
core   +1 more source

Influence of Short Cationic Lipopeptides with Fatty Acids of Different Chain Lengths on Bacterial Biofilms Formed on Polystyrene and Hydrogel Surfaces

Pharmaceutics, 2019
Nowadays, biomaterials are applied in many different branches of medicine. They significantly improve the patients’ comfort and quality of life, but also constitute a significant risk factor for biofilm-associated infections.
Malgorzata Anna Paduszynska, Magdalena Maciejewska, Damian Neubauer, Krzysztof Golacki, Magdalena Szymukowicz, Marta Bauer, Wojciech Kamysz   +6 more
doaj   +1 more source

Capra cartilage-derived peptide delivery via carbon nano-dots for cartilage regeneration

Frontiers in Bioengineering and Biotechnology, 2023
Targeted delivery of site-specific therapeutic agents is an effective strategy for osteoarthritis treatment. The lack of blood vessels in cartilage makes it difficult to deliver therapeutic agents like peptides to the defect area.
Priti Prasanna Maity, Kausik Kapat, Puja Poddar, Hema Bora, Chandan Kanta Das, Poushali Das, Sayan Ganguly, Narayan Chandra Das, Dibakar Dhara, Mahitosh Mandal, Amit Roy Chowdhury, Sumanta Mukherjee, Santanu Dhara   +12 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The use of chemically stabilised proteolytic enzymes in peptide synthesis [PDF]

, 2003
The aim of this project was to study various serine proteases, both native and chemically modified, with a view to their application in peptide synthesis.
Colleary, Sandra
core  

Chemical synthesis of tripeptide thioesters for the biotechnological incorporation into the myxobacterial secondary metabolite argyrin via mutasynthesis

Beilstein Journal of Organic Chemistry, 2019
The argyrins are secondary metabolites from myxobacteria with antibiotic activity against Pseudomonas aeruginosa. Studying their structure–activity relationship is hampered by the complexity of the chemical total synthesis.
David C. B. Siebert, Roman Sommer, Domen Pogorevc, Michael Hoffmann, Silke C. Wenzel, Rolf Müller, Alexander Titz   +6 more
doaj   +1 more source

Protective Effect of Peptides from Pinctada Martensii Meat on the H₂O₂-Induced Oxidative Injured HepG2 Cells

Antioxidants, 2023
Pinctada martensii is a major marine pearl cultured species in southern China, and its meat is rich in protein, which is an excellent material for the preparation of bioactive peptides.
Jie Zhou, Mengfen Wei, Lijun You
doaj   +1 more source