Results 61 to 70 of about 3,503,980 (299)

Studies in peptide chemistry [PDF]

, 1988
The thesis discusses the design of potential inhibitors of Angiotensin Converting Enzyme (ACE). The synthesis of pep tide inhibitors containing arginine and histidine-type residues is described.
Thomas, D. W.
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Enhancing the Oral Bioavailability of Glutathione Using Innovative Analogue Approaches

Pharmaceutics
Background: Glutathione (GSH) is an essential antioxidant that protects against oxidative stress, but its oral bioavailability is below 1% due to enzymatic degradation and poor gastrointestinal absorption.
Naibo Yin, Paul W. R. Harris, Mengyang Liu, Jianguo Sun, Guanyu Chen, Jingyuan Wen, Margaret A. Brimble   +6 more
doaj   +1 more source

Peptides derived from hookworm anti-inflammatory proteins suppress inducible colitis in mice and inflammatory cytokine production by human cells

Frontiers in Medicine, 2022
A decline in the prevalence of parasites such as hookworms appears to be correlated with the rise in non-communicable inflammatory conditions in people from high- and middle-income countries.
Claudia Cobos, Paramjit S. Bansal, David T. Wilson, Linda Jones, Guangzu Zhao, Matthew A. Field, Matthew A. Field, Matthew A. Field, Ramon M. Eichenberger, Darren A. Pickering, Rachael Y. M. Ryan, Champa N. Ratnatunga, John J. Miles, Roland Ruscher, Paul R. Giacomin, Severine Navarro, Severine Navarro, Severine Navarro, Alex Loukas, Norelle L. Daly   +19 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Cationic Linear Scorpion Peptide Mucroporin Displays Antimicrobial Activity against Neisseria Subflava

Proceedings
The emergence of antibiotic resistance makes the development of a new generation of powerful antimicrobials able to kill super bugs more essential than ever [...]
Anastasia Micha, Tolis Panayi, Christos Petrou, Yiannis Sarigiannis   +3 more
doaj   +1 more source

Synthesis of Peptide Bioconjugates [PDF]

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
openaire   +2 more sources

Peptide transport in Candida albicans and synthetic antifungal agents [PDF]

, 1986
These studies have characterized the peptide transport systems of Candida albicans, with a view to the rational design of peptide antifungal agents exploiting the 'smugglin' concept.
Shallow, David A.
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source