Results 1 to 10 of about 900,801 (302)
Leader peptide removal in lasso peptide biosynthesis based on penultimate isoleucine residue [PDF]
Frontiers in Microbiology, 2023 Lasso peptides are ribosomally synthesized peptides that undergo post-translational modifications including leader peptide removal by B (or the segregated B1 and B2) proteins and core peptide macrolactamization by C proteins to form a unique lariat ...
Yuwei Duan +11 more
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A Nonribosomal System of Peptide Biosynthesis [PDF]
FEBS Journal, 1996 This review covers peptide structures originating from the concerted action of enzyme systems without the direct participation of nucleic acids. Biosynthesis proceeds by formation of linear peptidyl intermediates which may be enzymatically modified as well as transformed into specific cyclic structures.
Horst Kleinkauf +2 more
exaly +3 more sources
Molecular basis for depsipeptide HDAC inhibitor combinatorial biosynthesis [PDF]
Nature CommunicationsPolyketides and nonribosomal peptides are important natural product classes with wide-ranging medical and agricultural applications. The analogous enzymatic logic employed by bacterial modular polyketide synthases (PKSs) and nonribosomal peptide ...
Munro Passmore +8 more
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PLoS ONE, 2023 Large peptide biosynthesis is a valuable alternative to conventional chemical synthesis. Enfuvirtide, the largest therapeutic peptide used in HIV infection treatment, was synthesized in our thermostable chaperone-based peptide biosynthesis system and ...
Vladimir Zenin +4 more
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Expression and Activity Identification of Recombinant Antihypertensive Peptide (Angiotensin I-Converting Enzyme Inhibitory Peptide) [PDF]
Shipin Kexue, 2023 In this study, the antihypertensive peptide WQVLPNAVPAK was selected for the synthesis of the gene encoding the hexameric peptide angiotensin I-converting enzyme inhibitory peptide (ACEIP) based on the codon preference of Escherichia coli.
DI Nana, JIANG Bo, ZHANG Ran, CAO Hongzhen, CHEN Jingjing, ZHANG Tao
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Frontiers in Bioengineering and Biotechnology, 2021 Surfactin is a lipoheptapeptide produced by several Bacillus species and identified for the first time in 1969. At first, the biosynthesis of this remarkable biosurfactant was described in this review.
Ariane Théatre +16 more
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Enfuvirtide biosynthesis in thermostable chaperone-based fusion
Biotechnology Reports, 2022 Synthetic peptides are in high demand as biologically active substances. Solid phase synthesis is the primary method of peptide production. However, it has drawbacks: large amount of chemical waste and rapid increase in price with peptide length ...
Vladimir Zenin +3 more
doaj +1 more source
mBio, 2021 Lantibiotics are ribosomally synthesized and posttranslationally modified peptide antibiotics. Although the membrane-associated lantibiotic biosynthesis machinery has long been proposed to exist, the isolation of such a complex has not been reported yet,
Jingqi Chen, Oscar P. Kuipers
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Antibiotics, 2023 Dithiolopyrrolone antibiotics are well known for their outstanding biological activities, and their biosynthesis has been studied vigorously. However, the biosynthesis mechanism of the characteristic bicyclic scaffold is still unknown after years of ...
Yan Chen +4 more
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Structural Basis for the Peptidoglycan-Editing Activity of YfiH
mBio, 2022 Bacterial cells are encased in peptidoglycan (PG), a polymer of disaccharide N-acetylglucosamine (GlcNAc) and N-acetyl-muramic acid (MurNAc) cross-linked by peptide stems.
Meng-Sheng Lee +6 more
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