Results 21 to 30 of about 200,892 (306)

Running rings around proteins: Protease-mediated biosynthesis of circular peptide and proteins Published abstract [PDF]

, 2020
Ribosomally synthesized cyclic peptides ranging in size from 10-80 amino acids have been discovered in bacteria, plants and animals over the last decade [1]. Their head-totail cyclic peptide backbone, which means they are devoid of N- or C-termini, makes
Colgrave, Michelle L, Anderson , Marilyn, Conlan, Brendon, Mylne, J, Craik, David J   +4 more
core   +1 more source

Genetic and functional characterization of the gene cluster directing the biosynthesis of putisolvin I and II in Pseudomonas putida strain PCL1445 [PDF]

, 2008
Pseudomonas putida PCL1445 secretes two cyclic lipopeptides, putisolvin I and putisolvin II, which possess a surface-tension-reducing ability, and are able to inhibit biofilm formation and to break down biofilms of Pseudomonas species including ...
Dubern, J.F., Stiekema, W.J., Coppoolse, E.R., Bloemberg, G.V.   +3 more
core   +1 more source

Exploring the selectivity and engineering potential of an NRPS condensation domain involved in the biosynthesis of the thermophilic siderophore fuscachelin

Frontiers in Catalysis, 2023
In nonribosomal peptide synthesis, condensation (C) domains are key catalytic domains that most commonly link carrier protein bound substrates to form peptides or depsipeptides.
Y. T. Candace Ho, Y. T. Candace Ho, Y. T. Candace Ho, Y. T. Candace Ho, Thierry Izoré, Thierry Izoré, Joe A. Kaczmarski, Joe A. Kaczmarski, Edward Marschall, Edward Marschall, Edward Marschall, Minuri S. Ratnayake, Minuri S. Ratnayake, Minuri S. Ratnayake, Julien Tailhades, Julien Tailhades, Julien Tailhades, David L. Steer, David L. Steer, Ralf B. Schittenhelm, Ralf B. Schittenhelm, Manuela Tosin, Colin J. Jackson, Colin J. Jackson, Colin J. Jackson, Colin J. Jackson, Max J. Cryle, Max J. Cryle, Max J. Cryle   +28 more
doaj   +1 more source

Regulation of cyclic lipopeptide biosynthesis in Pseudomonas fluorescens by the ClpP protease [PDF]

, 2009
Cyclic lipopeptides produced by Pseudomonas species exhibit potent surfactant and broad-spectrum antibiotic properties. Their biosynthesis is governed by large multimodular nonribosomal peptide synthetases, but little is known about the genetic ...
Bruijn, I., de, Raaijmakers, J.M., de Bruijn, I.   +2 more
core   +1 more source

iTRAQ-BASED Proteomic Analysis of the Mechanism of Fructose on Improving Fengycin Biosynthesis in Bacillus Amyloliquefaciens

Molecules, 2021
Fengycin, as a lipopeptide produced by Bacillus subtilis, displays potent activity against filamentous fungi, including Aspergillus flavus and Soft-rot fungus, which exhibits a wide range of potential applications in food industries, agriculture, and ...
Hedong Lu, Ruili Li, Panping Yang, Weibo Luo, Shunxian Chen, Muhammad Bilal, Hai Xu, Chengyuan Gu, Shuai Liu, Yuping Zhao, Chengxin Geng, Li Zhao   +11 more
doaj   +1 more source

The benzodiazepine-like natural product tilivalline is produced by the entomopathogenic bacterium Xenorhabdus eapokensis. [PDF]

PLoS ONE, 2018
The pyrrolobenzodiazepine tilivalline (1) was originally identified in the human gut pathobiont Klebsiella oxytoca, the causative agent of antibiotic-associated hemorrhagic colitis.
Hendrik Wolff, Helge B Bode
doaj   +1 more source

Functional production of clostridial circularin A in Lactococcus lactis NZ9000 and mutational analysis of its aromatic and cationic residues

Frontiers in Microbiology, 2022
Circular bacteriocins, also known as bacterial head-to-tail cyclized peptides, are a subgroup of ribosomally synthesized and post-translationally modified peptides (RiPPs).
Fangfang Liu, Auke J. van Heel, Jingqi Chen, Oscar P. Kuipers   +3 more
doaj   +1 more source

Put a Bow on It: Knotted Antibiotics Take Center Stage

Antibiotics, 2019
Ribosomally-synthesized and post-translationally modified peptides (RiPPs) are a large class of natural products produced across all domains of life. The lasso peptides, a subclass of RiPPs with a lasso-like structure, are structurally and functionally ...
Stephanie Tan, Gaelen Moore, Justin Nodwell   +2 more
doaj   +1 more source

Linking Peptide and Polyketide Biosynthesis.

The Journal of Antibiotics, 1995
organic chemist, natural chemistry within living organisms operates with protein catalysts. These catalysts assemble the reactants and perform their tasks in general in neutral aqueous media at ambient temperatures. To perform the synthesis of a complex metabolite, the proteins mayhave to interact in various ways.
H, Kleinkauf, H, von Döhren
openaire   +3 more sources

Expression and purification of an adenylation domain from a eukaryotic nonribosomal peptide synthetase: Using structural genomics tools for a challenging target [PDF]

, 2010
Nonribosomal peptide synthetases (NRPSs) are large multimodular and multidomain enzymes that are involved in synthesising an array of molecules that are important in human and animal health.
Lee, TV, Arcus, VL, Lott, JS, Johnson, RD, Lott, J. Shaun, Vickery L. Arcus, Johnson, Richard D., Arcus, Vickery L., J. Shaun Lott, Richard D. Johnson, T. Verne Lee, Lee, T. Verne   +11 more
core   +1 more source