Results 71 to 80 of about 1,857,199 (369)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Solid‐Phase Synthesis of Oligosaccharides
ChemInform, 2004 AbstractFor Abstract see ChemInform Abstract in Full Text.
Diederichsen, Ulf, Wagner, Thomas
openaire +2 more sources
Origin of the structural phase transition in Li7La3Zr2O12
, 2012 Garnet-type Li7La3Zr2O12 (LLZO) is a solid electrolyte material with a low-conductivity tetragonal and a high-conductivity cubic phase. Using density-functional theory and variable cell shape molecular dynamics simulations, we show that the tetragonal ...
E. B. Tadmor +3 more
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
SASRIN™ a Versatile Tool in Peptide Synthesis and Solid-Phase Organic Chemistry
CHIMIA, 1999 The synthesis of the 4-(3-methoxy-4-(hydroxymethyl)phenoxymethyl) derivative of polystyrene-co-divinylbenzene (SASRIN™), its derivatives and its application in solid-phase peptide synthesis will be briefly reviewed in this paper.
Monika Mergler +4 more
doaj
Solid Phase Formylation of N-Terminus Peptides
Molecules, 2016 Formylation of amino groups is a critical reaction involved in several biological processes including post-translational modification of histones. The addition of a formyl group (CHO) to the N-terminal end of a peptide chain generates biologically active
Anna Lucia Tornesello +2 more
doaj +1 more source
Finite element formulation to study thermal stresses in nanoencapsulated phase change materials for energy storage [PDF]
, 2020 Nanoencapsulated phase change materials (nePCMs) – which are composed of a core with a phase change material and of a shell that envelopes the core – are currently under research for heat storage applications. Mechanically, one problem encountered in the
Forner Escrig, Josep +2 more
core +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Synthèse de molécules d'intérêt biologique. Contribution à la synthèse des bastadines [PDF]
Biotechnologie, Agronomie, Société et Environnement, 2010 Synthesis of molecules of biological interest. Contribution to the synthesis of bastadins. The metabolites are a biochemical area whose interest is in constant progression.
Decamps, C. +4 more
doaj
DNA-Encoded Solid-Phase Synthesis: Encoding Language Design and Complex Oligomer Library Synthesis
ACS Combinatorial Science, 2015 The promise of exploiting combinatorial synthesis for small molecule discovery remains unfulfilled due primarily to the “structure elucidation problem”: the back-end mass spectrometric analysis that significantly restricts one-bead-one-compound (OBOC ...
Andrew B. MacConnell +3 more
semanticscholar +1 more source