Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Development of a modular directional and spectral neutron detection system using solid-state detectors [PDF]
, 2020 Keywords: Microstructured solid-state neutron detector Directional and spectral neutron detection Special nuclear material MCNP a b s t r a c t A detection system using room-temperature, microstructured solid-state thermal neutron detectors with very low
L Mcelwain +7 more
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
A study of radon emitted from building materials using solid state nuclear track detectors
Journal of Radiation Research and Applied Sciences, 2015 Radon is a natural radioactive gas derived from geologic materials. Inhalation of the short-lived decay products of radon has been linked to an increase in the risk of developing lung cancers if present at elevated levels.
Rafat M. Amin
doaj +1 more source
Monte-Carlo calculation of output correction factors for ionization chambers, solid-state detectors, and EBT3 film in small fields of high-energy photons. [PDF]
J Appl Clin Med Phys, 2023 Klimanov VA +7 more
europepmc +1 more source
Matched direction detectors and estimators for array processing with subspace steering vector uncertainties [PDF]
, 2005 In this paper, we consider the problem of estimating and detecting a signal whose associated spatial signature is known to lie in a given linear subspace but whose coordinates in this subspace are otherwise unknown, in the presence of subspace ...
Besson, Olivier +2 more
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Accuracy of HVL measurements utilizing solid state detectors for radiography and fluoroscopy X-ray systems. [PDF]
J Appl Clin Med Phys, 2021 Lin PP, Goode AR.
europepmc +1 more source
Solid-state-biased coherent detection of ultra-broadband terahertz pulses [PDF]
, 2017 Significant progress in nonlinear and ultrafast optics has recently opened new and exciting opportunities for terahertz (THz) science and technology, which require the development of reliable THz sources, detectors, and supporting devices.
Matteo Clerici (4483945) +15 more
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