Results 71 to 80 of about 53,794 (307)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

TRACK FORMATION BY α-PARTICLES IN THE SOLID STATE TRACK DETECTORS

Вестник. Серия физическая, 2009
The nuclear and atomic mechanisms interaction of the incident α-particles with substance of the solidstate track detectors that consist of polyethylene terephthalate and its analogs realized. The geometry ofprimary abeyance track was constructed as basic
V.V. D’yachkov, A.V. Yushkov
doaj  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Neutron detection devices with 6LiF converter layers

EPJ Web of Conferences, 2018
The demand for new thermal neutron detectors as an alternative to 3He tubes in research, industrial, safety and homeland security applications, is growing.
Finocchiaro Paolo, Cosentino Luigi, Meo Sergio Lo, Nolte Ralf, Radeck Desiree   +4 more
doaj   +1 more source

Gamma and neutron dose measurements with solid state nucleartrack detectors [PDF]

, 2009
An attempt has been made to explore the possibility of using solid state nuclear track detectors for the estimation of gamma and neutron doses based on the use of changes in activation energy of degradation of these detectors, due to irradiation (gamma ...
Kalsi, P C
core  

Investigation of latent ion tracks in SSNTD with small angle neutron scattering [PDF]

, 2022
S.29-35Passing the SSNTD (solid state nuclear track detector) charged particles (protons and heavier) form latent tracks. The parameters of these tracks vary with the atomic number and the energy of particles.
Häußler, F., Stetsenko, S.G., Birkholz, W.   +2 more
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Geiger-Mode Avalanche Photodiode Arrays Integrated to All-Digital CMOS Circuits

Sensors, 2016
This article reviews MIT Lincoln Laboratory's work over the past 20 years to develop photon-sensitive image sensors based on arrays of silicon Geiger-mode avalanche photodiodes.
Brian Aull
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Solid State Detectors and Tracking for Snowmass

, 2022
Tracking detectors are of vital importance for collider-based high energy physics (HEP) experiments. The primary purpose of tracking detectors is the precise reconstruction of charged particle trajectories and the reconstruction of secondary vertices.
Affolder, A., Apresyan, A., Worm, S., Albrow, M., Ally, D., Ambrose, D., Anderssen, E., Apadula, N., Asenov, P., Armstrong, W., Artuso, M., Barbier, A., Barletta, P., Bauerdick, L., Berry, D., Bomben, M., Boscardin, M., Brau, J., Brooks, W., Breidenbach, M., Buckley, J., Cairo, V., Caputo, R., Carpenter, L., Centis-Vignali, M., Cerullo, M., Collu, A., Chlebana, F., Dalla-Betta, G. -F., Demarteau, M., Deptuch, G., Di Petrillo, K., D'Amen, G., Dragone, A., Fourches, N. T., Garcia-Sciveres, M., Giacomini, G., Gingu, C., Graf, N., Grace, C., Griso, S., Greiner, L., Haber, C., Haller, G., Harris, K., Heim, T., Heinz, U., Heller, R., Hedges, M. T., Herbst, R., Hoeferkamp, M. R., Holmes, T., Holland, S. E., Hsu, S. -C., Islam, R., Jadhav, M., Jindariani, S., Joosten, S., Jung, A., Karmarkar, S., Kenney, C., Kierans, C., Kim, J., Kim, S., Klein, S., Koshy, A., Krizka, K., Lai, A., Lee, L., Linssen, L., Lipton, R., Liu, T., Madrid, C., Mahajan, T., Markiewicz, T., Markovic, B., Mazza, S., Mazziotta, M., Mei, Y., Merkel, P., Metcalfe, J., Meziani, Z. -E., Minns, A., Moscatelli, F., Murat, P., Muth, J., Nachman, B., Nahn, S., Narain, M., Narayanan, E. A., Nelson, T., Nielsen, J., Oktyabrsky, S., Ott, J., Palomo, F. R., Passeri, D., Patti, R., Peltola, T., Pena, C., Peng, C., Renard, C., Reimer, P., Rogan, C., Rota, L., Sadrozinski, H., Segal, J., Schwartzman, A., Schumm, B., Scott, M., Seidel, S., Seiden, A., Sekely, B., Shi, X., Sichtermann, E., Sinev, N., Sonneveld, J., Spiegel, L., Steinhebel, A., Strom, D., Sultan, D. M. S., Sumant, A., Tokranov, V., Tricoli, A., Trischuk, W., Tumasyan, A., Uplegger, L., Vernieri, C., Wang, H., Wagenknecht, P., Weber, H., Xie, S., Yakimov, M., Ye, Z., Young, C., Zurek, M.   +134 more
openaire   +2 more sources