Results 51 to 60 of about 53,794 (307)

Comparison of silicon drift detectors made by Amptek and PNDetectors in application to the PHA system for W7-X

Nukleonika, 2016
The paper presents comparison of two silicon drift detectors (SDD), one made by Amptek, USA, and the second one by PNDetector, Germany, which are considered for a soft X-ray diagnostic system for W7-X.
Krawczyk Natalia, Kaczmarczyk Jacek, Kubkowska Monika, Ryć Leszek   +3 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

A Solid State Directional Gamma Detector [PDF]

IEEE Transactions on Nuclear Science, 1986
A solid-state gamma-ray detector has been developed which exhibits directionality. Four PIN diode detectors are backed with Pb and arranged in a square array which exhibits an angular response to gamma rays. The high-Z material provides directionality and also enhances the sensitivity of the detectors to high-energy gammas by means of the x-ray ...
Baird, W., Unruh, W. P., Bjarke, G. O., Beauchamp, P. K.   +3 more
openaire   +1 more source

A New Approach to Enhancing Radiation Hardness in Advanced Nuclear Radiation Detectors Subjected to Fast Neutrons

Instruments
Low-Gain Avalanche Diodes (LGADs) are critical sensors for the ATLAS and CMS timing detectors at the High Luminosity Large Hadron Collider (HL-LHC), offering enhanced timing resolution with gain factors of 20 to 50.
Aref Vakili, Mahsa Farasat, Antonino La Magna, Markus Italia, Lucio Pancheri   +4 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

A Characterization System for the Monitoring of ELI-NP Gamma Beam

Proceedings, 2019
The ELI-NP (Extreme Light Infrastructure-Nuclear Physics) facility, currently under construction near Bucharest (Romania), is the pillar of the project ELI dedicated to the generation of high-brilliance gamma beams and high-power laser pulses that will ...
Rita Borgheresi, Oscar Adriani, Sebastiano Albergo, Mirco Andreotti, Gigi Cappello, Paolo Cardarelli, Roberto Ciaranfi, Elisabetta Maria Grazia Consoli, Giovanni Di Domenico, Federico Evangelisti, Mauro Gambaccini, Giacomo Graziani, Michela Lenzi, Fernando Maletta, Michele Marziani, Giovanni Passaleva, Gianfranco Paternò, Alin Serban, Stefano Squerzanti, Oleksandr Starodubtsev, Alessia Tricomi, Matteo Turisini, Alessandro Variola, Michele Veltri, Bruno Zerbo   +24 more
doaj   +1 more source

Differentiating multi-MeV, multi-ion spectra with CR-39 solid-state nuclear track detectors

Scientific Reports, 2023
The development of high intensity petawatt lasers has created new possibilities for ion acceleration and nuclear fusion using solid targets. In such laser-matter interaction, multiple ion species are accelerated with broad spectra up to hundreds of MeV ...
M. S. Schollmeier, J. J. Bekx, J. Hartmann, E. Schork, M. Speicher, A. F. Brodersen, A. Fazzini, P. Fischer, E. Gaul, B. Gonzalez-Izquierdo, M. M. Günther, A. K. Härle, R. Hollinger, K. Kenney, J. Park, D. E. Rivas, V. Scutelnic, Z. Shpilman, S. Wang, J. J. Rocca, G. Korn   +20 more
doaj   +1 more source

Physical limitations to the spatial resolution of solid-state detectors [PDF]

, 2014
In this paper we explore the effect of -ray emission and fluctuations in the signal deposition on the detection of charged particles in silicon-based detectors.
Schwenker, Benjamin, Vos, M., Wilk, F., Marinas, Carlos, Boronat, M., Frey, Alexandra, Schwenker, B., Marinas, C., Vos, Marc A., Frey, A., Garcia, I.   +10 more
core   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source