Results 61 to 70 of about 53,794 (307)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Li–Pd–Rh-D2O electrochemistry experiments at elevated voltage

APL Energy, 2023
In 2013, the U.S. Navy disclosed an electrochemistry procedure intended to produce MeV-energy nuclear particles, based on eV-energy electrical inputs, which may be indicative of a new scientific phenomenon.
Carl Gotzmer, Louis F. DeChiaro, Kenneth Conley, Marc Litz, Marshall Millett, Jesse Ewing, Lawrence P. Forsley, Karen J. Long, William A. Wichart, Pamela A. Mosier-Boss, John Sullivan, Efrem Perry Jr, Oliver M. Barham   +12 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Solid-State Detector for FLASH Radiotherapy: Dosimetric Applications and Emerging Concepts

Condensed Matter
The implementation of FLASH Radiotherapy (FLASH-RT), characterized by ultra-high dose rates (UHDRs) frequently exceeding 106 Gy/s in microsecond pulses, imposes stringent requirements on real-time dosimetry. Conventional ionization chambers suffer severe
Pablo P. Yepes
doaj   +1 more source

A new method of imaging particle tracks in solid state nuclear track detectors [PDF]

, 2010
Solid state nuclear track detectors are used to determine the concentration of α particles in the environment. The standard method for assessing exposed detectors involves 2D image analysis.
Wertheim, D, Petford, N., Ivison, Claire, Petford, N, Gillmore, G, Brown, L., Wertheim, D., Gillmore, G., Brown, L   +8 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Characterisation of 3D trench silicon pixel sensors irradiated at 1⋅1017 1 MeV neqcm-2

Frontiers in Physics
The 3D trench silicon pixel sensors developed by the TimeSPOT collaboration have demonstrated exceptional performance, even after exposure to extreme radiation fluences up to 1⋅1017 1 MeV neq/cm2.
M. Addison, A. Bellora, A. Bellora, F. Borgato, F. Borgato, D. Brundu, D. Brundu, A. Cardini, G. M. Cossu, G. F. Dalla Betta, G. F. Dalla Betta, L. La Delfa, A. Lai, A. Lampis, A. Loi, M. M. Obertino, M. M. Obertino, S. Vecchi, M. Verdoglia, M. Verdoglia   +19 more
doaj   +1 more source

Neutron field spatial distribution from the DD neutron source determined by the KOSTKA experimental device [PDF]

EPJ Web of Conferences
The spatial distribution of neutrons plays a crucial role in characterizing the neutron source. In this experiment, solid-state nuclear track detectors made of polyallyl diglycol carbonate (PADC) were selected for this purpose.
Vrtalová Vendula, Vrban Branislav, Lüley Jakub, Čerba Štefan, Sedlák Matúš, Révai Filip, Glavo Otto, Nečas Vladimír   +7 more
doaj   +1 more source

New generation of highly sensitive radon detectors based on activated carbon with compensated temperature dependence

Scientific Reports, 2022
Recently patented compensation module for sensors of radioactive noble gases paves the way for novel designs of radon detectors/monitors with adsorbents, suitable for long-term measurements.
Dobromir Pressyanov
doaj   +1 more source

Light-emitting diodes and photodiodes in the deep ultra-violet range for absorption photometry in liquid chromatography, capillary electrophoresis and gas sensing [PDF]

, 2016
Absorbance measurement in the deep ultra-violet range (below 300 nm) has been one of the most widely used detection methods for analytical techniques as a large number of organic compounds have strong absorption bands in the deep UV region.
Bui, Duy Anh
core   +1 more source