Results 61 to 70 of about 640,424 (347)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Comparing the effects of two different vitamin regimens on bone metabolism for meat ducks at starting phase

Italian Journal of Animal Science
Objective Leg problems including lameness and tibial dyschondroplasia (TD) are one of the most important factors affecting health and animal welfare in meat-type poultry, which are considerably impacted by dietary vitamin regimens.
Ling Zhou, Pinyao Zhao, Yan Liu, Wei Zhao, Anran Jiao   +4 more
doaj   +1 more source

Production and statistical optimization of Paromomycin by Streptomyces rimosus NRRL 2455 in solid state fermentation

BMC Microbiology, 2021
Background Paromomycin is a 2-deoxystreptamine aminocyclitol aminoglycoside antibiotic with broad spectrum activity against Gram-negative, Gram-positive bacteria and many protozoa. This study introduces a strategy for paromomycin production through solid-
Ghadir S. El-Housseiny, Asmaa A. Ibrahim, Mahmoud A. Yassien, Khaled M. Aboshanab   +3 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Prokaryotic evolution shapes specialized communities in long term engineered pit mud ecosystem

npj Biofilms and Microbiomes
Elucidating the temporal dynamics of complex microbial consortia is crucial for engineering robust microbiome. We investigated prokaryotic evolution in pit mud, a centuries-old engineered environment used in Chinese liquor fermentation.
Yan Zeng, Xiaozhong Zhong, Lijuan Chai, Xiaojuan Zhang, Zhenming Lu, Guangqian Liu, Tingyao Tu, Lingfei Lu, Rui Zhang, Hui Yu, Suyi Zhang, Songtao Wang, Caihong Shen, Jinsong Shi, Zhenghong Xu   +14 more
doaj   +1 more source

Enhanced nutritional value of chickpea protein concentrate by dry separation and solid state fermentation

, 2020
A sustainable dry processing method to obtain nutritional and functional chickpea products was developed, yielding protein concentrates suited to prepare products without additives.
Qinhui Xing, S. Dekker, K. Kyriakopoulou, R. Boom, E. Smid, M. Schutyser   +5 more
semanticscholar   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Potential of solid state fermentation for production of ergot alkaloids

, 1992
Production of total ergot alkaloids by Clauiceps fusiformis in solid state fermentation was 3.9 times higher compared to that in submerged fermentation.
Lonsane, B. K., Trejo Hernandez, M. R., Raimbault, M., Roussos, S.   +3 more
core   +2 more sources

Variations of Soybean Meal and Corn Mixed Substrates in Physicochemical Characteristics and Microbiota During Two-Stage Solid-State Fermentation

Frontiers in Microbiology, 2021
Corn germ meal (CGM) and corn gluten feed (CGF) are the two main corn byproducts (CBs) obtained from corn starch extraction. Due to their high fiber content, low protein content, and severe imbalance of amino acid, CBs are unable to be fully utilized by ...
Weifa Su, Zipeng Jiang, Lihong Hao, Wentao Li, Tao Gong, Yu Zhang, S. Du, Cheng Wang, Zeqing Lu, Mingliang Jin, Yizhen Wang   +10 more
semanticscholar   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source