Results 41 to 50 of about 144,966 (302)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Prokaryotic evolution shapes specialized communities in long term engineered pit mud ecosystem
npj Biofilms and MicrobiomesElucidating the temporal dynamics of complex microbial consortia is crucial for engineering robust microbiome. We investigated prokaryotic evolution in pit mud, a centuries-old engineered environment used in Chinese liquor fermentation.
Yan Zeng +14 more
doaj +1 more source
Lignocellulose as raw material in fermentation processes [PDF]
, 2010 Lignocellulose in the form of forestry, agricultural, and agro-industrial wastes is accumulated in large quantities every year. These materials are mainly composed of three groups of polymers, namely cellulose, hemicellulose, and lignin.
Mussatto, Solange I., Teixeira, J. A.
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecules, 2021 Solid-state fermentation may produce therapeutic compounds with higher biomass or better product characteristics than those generated by submerged fermentation.
Jui-Yi Hsu +3 more
doaj +1 more source
Alkaline protease production by solid state fermentation on polyurethane foam [PDF]
, 2006 This paper investigated the process of solid state fermentation (SSF) using PUF (polyurethane foam) as inert solid support to produce alkaline protease. Maximal enzyme activity was 2185U/ml at pH 9.0, incubation temperature 32 0C inoculum amount of 1.0 %
Chen Hongzhang +3 more
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Research progress of solid-state pure culture equipment and technology [PDF]
Zhongguo niangzaoSolid-state pure culture is a biotechnology that simulates the natural fermentation environment. It uses solid matrix such as rice, bran, soybean meal as the growth medium for industrial microorganisms to ferment and produce by single microbial strain ...
TAI Yanxiang, YANG Wen, LIU Huipeng, HONG Housheng
doaj +1 more source
Biotechnology Reports, 2021 A new method has been developed to increase the productivity of aspergilli - producers of extracellular proteinases based on their cultivation on vermiculite under solid-state fermentation conditions.
Alexander A. Osmolovskiy +4 more
doaj +1 more source
Effects of fungal treatment on the in vitro degradation of cassava [PDF]
, 2011 The objective of this experiment was to increase the nutrient value of cassava by the solid state fermentation technique (SSF). Peeled cassava root was fermented for 10 days under solid state fermentation culture with two different fungi (Aspergillus ...
Alimon, Abdul Razak +3 more
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