Results 221 to 230 of about 18,277,440 (272)

Redefining Carbon Electrodes as Hierarchically Designable Reaction Fields for Electrochemical Biosensing

Small, EarlyView.
This Perspective proposes viewing carbon electrodes as hierarchically designable reaction fields for electrochemical biosensing. Crystallinity, heteroatom dopants, edge sites, and pore size are highlighted as key structural variables governing electron transfer, mass transport, biomolecule immobilization, and local concentration.
Hiroshi Yuzawa, Tetsuji Itoh, Thidarut Laochai, Nadnudda Rodthongkum, Hirotomo Nishihara   +4 more
wiley   +1 more source

How We Simulate Nanopores

Small Methods, EarlyView.
Nanopore technology has revolutionized single‐molecule sensing, yet it suffers from an inherent interpretive challenge. Molecular dynamics has emerged as a go‐to method for determining the relationship between the structure of translocating molecules and the nanopore current signals.
Behzad Mehrafrooz, Xavier Mleziva, Meng Xu, Melika Shekari, Christopher Maffeo, Aleksei Aksimentiev   +5 more
wiley   +1 more source

Microfluidic Sample Compartmentalization for Biomolecular Concentration Quantification Using a Nanopore Sensor

Small Methods, EarlyView.
We compartmentalize samples into picoliter volumes using a microfluidic device, allowing us to determine biomolecular concentration by counting molecules to depletion within a known volume without calibration. By integrating a nanopore sensor for this counting process, we also obtain real‐time data on the size, shape, and conformation of each ...
Morteza Safari, Juliana Chawich, Ali Najafi Sohi, Martin Charron, Vincent Tabard‐Cossa, Michel Godin   +5 more
wiley   +1 more source

Solid-state nanopore sensing reveals conformational changes induced by a mutation in a neuron-specific tRNA ^Arg

Dutt S, Lai LB, Mehta R, Karawdeniya BI, Bandara YND, Clulow AJ, Glatt S, Gopalan V, Kluth P.   +8 more
europepmc   +1 more source

Denoise Stepwise Signals by Diffusion Model‐Based Approach

Small Methods, EarlyView.
This work presents SSDM, a diffusion‐model‐based framework for denoising stepwise signals in single‐molecule measurements. By learning the statistical structure of state transitions and noise, SSDM reconstructs signal levels and identifies transition time points more accurately than conventional approaches, enabling robust analysis of signals across ...
Xingdi Tong, Chenyu Wen
wiley   +1 more source

Comparative Analysis of Stress Adaptation in the Yeast Microbiome of Cactus

Yeast, EarlyView.
Yeasts and related fungi isolated from cacti or nearby non‐cactus plants were characterized phenotypically and genomically, revealing differences that hint at modes of adaptation to the cactus host. ABSTRACT Together with other fungi, yeasts make up a significant component of the plant microbiome. As the planet warms, cacti expand their range.
Alya N. Hussain, Kevin T. Fotso, Michael A. McMurray   +2 more
wiley   +1 more source

Integrated Analysis of HER2 Expression and ERBB2 Alterations in Bladder Cancer

Cancer Science, EarlyView.
Integrated analysis of 445 bladder cancers showed that HER2 membrane expression and ERBB2 amplification are distinct features. HER2 expression overlapped with NECTIN4 expression, whereas ERBB2 amplification was enriched in the LumU subtype and associated with poor prognosis.
Kensuke Hirosuna, Kazuki Nishimura, Moritoshi Sakamoto, Satoshi Tokushige, Keita Nakamori, Tomohisa Matsunaga, Yuki Yoshikawa, Takeshi Tsutsumi, Ryoichi Maenosono, Takuya Tsujino, Masahiko Ajiro, Haruhito Azuma, Akihide Yoshimi, Kazumasa Komura   +13 more
wiley   +1 more source

Long‐read sequencing‐based atlas of tissue‐specific expression of DNM1L transcript variants

The FEBS Journal, EarlyView.
Targeted long‐read sequencing resolves full‐length DNM1L (Drp1) isoforms and reveals conserved, tissue‐specific expression patterns across human and mouse tissues. Functional assays show that Drp1 isoforms differ in their ability to drive mitochondrial fission, independent of abundance, with specific exons modulating activity.
Feng Yan, Jafar S. Jabbari, Naomi X. L. Ling, Anne M. Kong, Jia Q. Truong, Marnie L. Maddock, Ayeshah A. Rosdah, Christopher G. Langendorf, Lifang Zhang, Jarmon G. Lees, Sebastian Bass‐Stringer, Danise Ann Onda, Alice Pébay, Mirella Dottori, Kim Loh, Jessica K. Holien, Sean Lal, Nadia M. Davidson, Jonathan S. Oakhill, Shiang Y. Lim   +19 more
wiley   +1 more source

Lymphocystis Disease in Endemic Aotearoa New Zealand Bully (Gobiomorphus cotidianus)

Journal of Fish Diseases, EarlyView.
ABSTRACT We detected lymphocystis disease virus (LCDV) for the first time in an Aotearoa New Zealand freshwater environment, from an individual common bully, toitoi, Gobiomorphus cotidianus (Eleotridae). Dinah's bully, Gobiomorphus dinae, and Kaharore bully, Gobiomorphus mataraerore, also exhibited gross nodular lesions on the fins but were not sampled.
Kate S. Hutson, Karthiga Kumanan, Anne Rolton, Emily C. Giles, Joy A. Becker, Maeve Ballantyne, Tim Hewison, Georgia S. Steel, Joshua Wardle, Ashley Webby, Bram T. M. Mulling   +10 more
wiley   +1 more source

Dissecting the genetic basis of climatic adaptation in wild relatives (Malus baccata) for climate‐resilient apple breeding

Journal of Integrative Plant Biology, EarlyView.
This comprehensive map of genetic variation in wild apple (Malus baccata) and set of key genes associated with adaptation to temperature, precipitation, and soil properties establishes a foundation for breeding climate‐resilient apple cultivars and conserving the genetic resources of wild crop relatives.
Ying Su, Yani Hao, Xuejing Cao, Lin Wang, Zhiqi Xu, Fan Zhang, Zhiyao Ma, Xu Wang, Jiacui Li, Tianrong Fan, Ruoyan Zhao, Zhongqi Liu, Wenrui Wang, Yingchun Zhang, Xuanwen Yang, Sifan Yang, Dajiang Wang, Kun Wang, Simiao Sun, Zichen Li, Wen Tian, Yanming Sun, Zhao Liu, Yanshuai Xu, Hua Xiao, Yanling Peng, Xiaodong Xu, Ruirui Liu, Xinmin Tian, Yongfeng Zhou, Yuan Gao   +30 more
wiley   +1 more source