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Recent Progress in Solid‐State Nanopores
Advanced Materials, 2018AbstractThe solid‐state nanopore has attracted much attention as a next‐generation DNA sequencing tool or a single‐molecule biosensor platform with its high sensitivity of biomolecule detection. The platform has advantages of processability, robustness of the device, and flexibility in the nanopore dimensions as compared with the protein nanopore, but ...
Kidan Lee +6 more
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Microfluidic multiplexing of solid-state nanopores
Journal of Physics: Condensed Matter, 2017Although solid-state nanopores enable electronic analysis of many clinically and biologically relevant molecular structures, there are few existing device architectures that enable high-throughput measurement of solid-state nanopores. Herein, we report a method for microfluidic integration of multiple solid-state nanopores at a high density of one ...
Tarun Jain +4 more
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Nature Reviews Materials, 2020
Nanopore-based sensors have established themselves as a prominent tool for solution-based, single-molecule analysis of the key building blocks of life, including nucleic acids, proteins, glycans and a large pool of biomolecules that have an essential role in life and healthcare.
Liang Xue +5 more
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Nanopore-based sensors have established themselves as a prominent tool for solution-based, single-molecule analysis of the key building blocks of life, including nucleic acids, proteins, glycans and a large pool of biomolecules that have an essential role in life and healthcare.
Liang Xue +5 more
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Nature Nanotechnology, 2007
The passage of individual molecules through nanosized pores in membranes is central to many processes in biology. Previously, experiments have been restricted to naturally occurring nanopores, but advances in technology now allow artificial solid-state nanopores to be fabricated in insulating membranes.
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The passage of individual molecules through nanosized pores in membranes is central to many processes in biology. Previously, experiments have been restricted to naturally occurring nanopores, but advances in technology now allow artificial solid-state nanopores to be fabricated in insulating membranes.
openaire +2 more sources
DNA Origami Gatekeepers for Solid‐State Nanopores
Angewandte Chemie, 2012DNA has it covered: DNA origami gatekeeper nanoplates convert nanopores in solid-state membranes into versatile devices for label-free macromolecular sensing applications. The custom apertures in the nanoplates can be chemically addressed for sequence-specific detection of DNA.
Ruoshan Wei +3 more
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Rescalable solid-state nanopores
AIP Conference Proceedings, 2017Nanopores in 10–30 nm thickness Si4N3 membranes were milled using Ga+ ions. Dose dependence of the hole diameter and shape was established and explained as resulting from the intensity distribution of the focused ion beam. The initial diameter of the milled pore is dependent on the full-width half-maximum of the axial portion of the beam, whereas shape
Armandas Balčytis +4 more
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Solid-State Nanopore Technologies for Nanopore-Based DNA Analysis
Nanomedicine, 2007Nanopore-based DNA analysis is a new single-molecule technique that involves monitoring the flow of ions through a narrow pore, and detecting changes in this flow as DNA molecules also pass through the pore. It has the potential to carry out a range of laboratory and medical DNA analyses, orders of magnitude faster than current methods.
Ken, Healy +2 more
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Solid-state nanopores and nanopore arrays optimized for optical detection
Nanoscale, 2014Controllable reduction of the local fluorescence around solid-state nanopores and nanopore arrays enables optical recognition of molecular translocations and a route towards massively-parallel detection.
Furat, Sawafta +4 more
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Fabrication of solid‐state nanopores and its perspectives
ELECTROPHORESIS, 2015Nanofluidics is becoming an extensively developing technique in the field of bioanalytical chemistry. Nanoscale hole embed in an insulating membrane is employed in a vast variety of sensing platforms and applications. Although, biological nanopores have several attractive characteristics, in this paper, we focused on the solid‐state nanopores due to ...
Jiri, Kudr +6 more
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Selective (Bio)Functionalization of Solid-State Nanopores
ACS Applied Materials & Interfaces, 2015We present a method to selectively (bio)functionalize nanoscale features with the same materials chemistry. It was successfully combined with nanosphere lithography to fabricate and functionalize solid-state nanopores with PEG-brushes, supported lipid membranes, and functional proteins over large areas.
Pla-Roca Mateu +3 more
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