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Portable nanopore-sequencing technology: Trends in development and applications
Frontiers in Microbiology, 2023 Sequencing technology is the most commonly used technology in molecular biology research and an essential pillar for the development and applications of molecular biology.
Pin Chen +13 more
doaj +1 more source
Thermostable virus portal proteins as reprogrammable adapters for solid-state nanopore sensors
Nature Communications, 2018 Solid state nanopores are robust but the sizing can be variable, whereas protein nanopores are precisely sized but lack robustness. Here the authors cork a solid state nanopore with the DNA-translocating portal protein from the virus G20c to obtain a ...
Benjamin Cressiot +4 more
doaj +1 more source
Trapping DNA near a Solid-State Nanopore [PDF]
, 2016 We demonstrate that voltage biased solid-state nanopores can transiently localize DNA in an electrolyte solution. A double-stranded DNA (dsDNA) molecule is trapped when the electric field near the nanopore attracts and immobilizes a non-end segment of ...
Vlassarev, Dimitar M. +1 more
core +1 more source
Characterization of Protein Unfolding with Solid-state Nanopores [PDF]
Protein & Peptide Letters, 2014 In this work, we review the process of protein unfolding characterized by a solid-state nanopore based device. The occupied or excluded volume of a protein molecule in a nanopore depends on the protein's conformation or shape. A folded protein has a larger excluded volume in a nanopore thus it blocks more ionic current flow than its unfolded form and ...
Jiali, Li +3 more
openaire +2 more sources
Surface coatings for solid-state nanopores
Nanoscale, 2019 Nanopores enable the characterization of single biomolecules; to interrogate these molecules without artifacts from wall interactions, nanopore coatings are required.
Olivia M. Eggenberger +2 more
openaire +4 more sources
Protein sensing using solid-state nanopore [PDF]
, 2018 Cytokines are small-molecule signaling proteins involved in cell-cell regulation. The detection of low-abundance cytokines is challenging since the currently available techniques are limited by sensitivity and are time-consuming.
Varongchayakul, Nitinun
core +1 more source
Characterization of Protein Aggregation Using a Solid-State Nanopore Device [PDF]
, 2021 Protein aggregation has been linked to many chronic and devastating neurodegenerative human diseases and is also strongly associated with aging. In the case of neurodegenerative diseases, α, β tubulins and tau proteins dissociate in a neuron cell and ...
Acharjee, Mitu Chandra
core +3 more sources
Statistics of DNA Capture by a Solid-State Nanopore
Physical Review Letters, 2013 A solid-state nanopore can electrophoretically capture a DNA molecule and pull it through in a folded configuration. The resulting ionic current signal indicates where along its length the DNA was captured. A statistical study using an 8 nm wide nanopore reveals a strong bias favoring the capture of molecules near their ends.
Mihovilovic, Mirna +2 more
openaire +4 more sources
Optofluidic devices with integrated solid-state nanopores [PDF]
Microchimica Acta, 2016 This review (with 90 refs.) covers the state of the art in optofluidic devices with integrated solid-state nanopores for use in detection and sensing. Following an introduction into principles of optofluidics and solid-state nanopore technology, we discuss features of solid-state nanopore based assays using optofluidics. This includes the incorporation
Shuo, Liu +2 more
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Solid‐State Nanopore Array: Manufacturing and Applications
Small, 2022 AbstractNanopore brings extraordinary properties for a variety of potential applications in various industrial sectors. Since manufacturing of solid‐state nanopore is first reported in 2001, solid‐state nanopore has become a hot topic in the recent years.
Hongshuai Liu +4 more
openaire +2 more sources