Results 61 to 70 of about 353,813 (260)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Dissolution Kinetics of a BCS Class II Active Pharmaceutical Ingredient: Diffusion-Based Model Validation and Prediction

ACS Omega, 2021
Yuan Gao, Brian Glennon, Yunliang He, Philip Donnellan   +3 more
doaj   +1 more source

Synthesis Methods in Solid-State Chemistry

, 2020
La síntesis del monocristal es un área de intensa actividad en la ciencia de los materiales. La obtención del monocristal con dimensión suficiente para la difracción de rayos X depende de varios factores, entre ellos la composición química, la estructura cristalina de los reactivos y los parámetros físicos (temperatura y presión).
Youssef Ben Smida, Riadh Marzouki, Savaş Kaya, Sultan Erkan, Mohamed Faouzi Zid, Ahmed Hichem Hamzaoui   +5 more
openaire   +2 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Theoretical fundamentals of mechanochemical reactions in the solid phase [PDF]

Podzemni Radovi
Chemical reactions in the solid phase are characterized by many specificities. The study of such reactions, with regard to the condensed state, eliminates the need to introduce many approximations that are common when considering reactions in the liquid ...
Đorđević Nataša, Mihajlović Slavica, Vlahović Milica, Kašić Vladan, Matijašević Srđan, Grubišić Mirko   +5 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Mechanochemistry vs Conventional Solid-State Synthesis: A Sustainable Development Pathway [PDF]

MATEC Web of Conferences
The shift to sustainable chemical manufacturing highlights the need for solid-state synthesis methods that minimize solvent use, energy consumption and environmental impact.
Chen Yinuo
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Linear paired electrolysis of furfural to furoic acid at both anode and cathode in a multiple redox mediated system

Green Energy & Environment
Implementing a new energy-saving electrochemical synthesis system with high commercial value is a strategy of the sustainable development for upgrading the bulk chemicals preparation technology in the future.
Xinxin Li, Linchuan Cong, Haibo Lin, Fangbing Liu, Xiangxue Fu, Hai-Chao Xu, Nan Lin   +6 more
doaj   +1 more source