Results 51 to 60 of about 353,813 (260)

Investigation of transport properties of hydroxyapatite and its silicon-substituted derivatives

Физико-химические аспекты изучения кластеров, наноструктур и наноматериалов
The article discusses the possibility of practical application of hydroxyapatite and silicon-substituted hydroxyapatite as components of medicines, pharmaceutical compositions, and biomaterials, the use of which is based on the transdermal delivery route
E.A. Bogdanova, T.G. Khonina, N.A. Sabirzyanov   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Study of the physico-chemical properties of composites obtained by mechanochemical synthesis of nanoscale hydroxyapatite and synthetic zeolites

Физико-химические аспекты изучения кластеров, наноструктур и наноматериалов
In this article, the features of synthesis and physicochemical properties of a composite material based on precipitated hydroxyapatite and synthetic aluminosilicate zeolites are investigated. Using modern methods of analysis, both the obtained composite
A.G. Shirokova, S.A. Bibanaeva, E.A. Bogdanova, V.M. Skachkov, O.V. Koryakova   +4 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Solid state synthesis of calcium borohydroxyapatite

Solid State Sciences, 2011
Abstract Calcium borohydroxyapatite was synthesized by the solid-state reaction of colemanite (Ca 2 B 6 O 11 ·5H 2 O) and diamonium hydrogenphosphate ((NH 4 ) 2 HPO 4 ) at 1200 °C for 12 h. X-ray diffraction pattern showed only the formation of calcium borohydroxyapatite. The experimental analysis assigned the chemical formula as Ca 10 [(PO 4 ) 5.80 (
Güler, Halil, Gündoğmaz, G., Kurtuluş, Figen, Çelik, Gülşah, Gacanoğlu, S. S.   +4 more
openaire   +2 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

The Function of Photocatalytic Performance and Carrier Separation Efficiency Tuned by Doping Content in Homogeneous Photocatalysts

Advanced Science
Homogeneous matrix materials are considered to be a solid guarantee of site‐point charge transfer reactions because they are the main body of light absorption, photogenerated carrier separation, migration, and recombination processes.
Chunxia Wen, Xinyue Ni, Mei Han, Yue Yu, Chuanqiang Liu, Yuan Zhang, Beining Zheng, Shouhua Feng   +7 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Utilising a 1,8-naphthalimide probe for the ratiometric fluorescent visualisation of caspase-3

Frontiers in Chemistry
The development of selective and sensitive probes for monitoring caspase-3 activity–a critical enzyme involved in apoptosis–remains an area of significant interest in biomedical research.
Conor Wynne, Conor Wynne, Robert B. P. Elmes, Robert B. P. Elmes, Robert B. P. Elmes   +4 more
doaj   +1 more source