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PI3K Targeting in Non-solid Cancer
2022Despite the therapeutic progress, relapse remains a major problem in the treatment of acute lymphoblastic leukemia (ALL). Most leukemia cells that survive chemotherapy are found in the bone marrow (BM), thus resistance to chemotherapy and other treatments may be partially attributed to pro-survival signaling to leukemic cells mediated by leukemia cell ...
Hye Na, Kim +4 more
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Cancer stem cells in solid tumors
Seminars in Cancer Biology, 2010According to the cancer progression model, several events are required for the progression from normal epithelium to carcinoma. Due to their extended life span, stem cells would represent the most likely target for the accumulation of these genetic events but this has not been formally proven for most of solid cancers.
Hermann PC +3 more
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Emergency myelopoiesis in solid cancers
British Journal of HaematologySummaryCells of the innate and adaptive immune systems are the progeny of haematopoietic stem and progenitor cells (HSPCs). During steady‐state myelopoiesis, HSPC undergo differentiation and proliferation but are called to respond directly and acutely to various signals that lead to emergency myelopoiesis, including bone marrow ablation, infections ...
Konstantinos Aliazis +3 more
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Leptomeningeal cancer in leukemia and solid tumors
Current Problems in Cancer, 1988Although some patients with overt leptomeningeal cancer can now be cured, the proportion of patients who survive is very small, and the cost of cure, in terms of neuropsychological and educational morbidity, is substantial. Yet the incidence of central nervous system infiltration of systemic cancer is generally increasing, in most instances because ...
W A, Bleyer, T N, Byrne
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Lactic Acidosis in Patients with Solid Cancer
Antioxidants & Redox Signaling, 2022Significance: Cancer-associated tissue-specific lactic acidosis stimulates and mediates tumor invasion and metastasis and is druggable. Rarely, malignancy causes systemic lactic acidosis, the role of which is poorly understood. Recent Advances: The understanding of the role of lactate has shifted dramatically since its discovery.
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Precision medicine in pediatric solid cancers
Seminars in Cancer Biology, 2022Despite huge advances in the diagnosis and treatment of pediatric cancers over the past several decades, it remains one of the leading causes of death during childhood in developed countries. The development of new targeted treatments for these diseases has been hampered by two major factors.
Mirjam Blattner-Johnson +2 more
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Risk of solid cancer after chemotherapy
Nature Reviews Urology, 2018Platinum-based chemotherapy continues to be linked with the subsequent development of various solid tumours. In a large analytical study of >5,800 survivors of testicular cancer, Groot and colleagues observed statistically significant dose-dependent increases in gastrointestinal cancer incidence after platinum-based chemotherapy, providing evidence for
Chunkit, Fung, Lois B, Travis
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Candidate gene polymorphisms in solid cancers
European Journal of Surgical Oncology (EJSO), 2004Accumulation of information from scientific advances in genetics and biotechnology has accelerated research investigating the inherent individual variation in disease susceptibility and severity. Gene polymorphisms, in particular single nucleotide polymorphisms, are being evaluated for their role in multi-factorial diseases such as cancer and ...
S P, Balasubramanian +3 more
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Immune thrombocytopenia associated with solid cancer
Journal of Obstetrics and Gynaecology Research, 2015AbstractWe describe a case of immune thrombocytopenia (ITP) associated with ovarian cancer. At the patient's first visit to hospital, high platelet‐associated IgG and low platelet count (74 × 109/L) were noted on blood test. She was diagnosed as having ITP complicated by ovarian cancer.
Takako, Shimada +6 more
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Cancer-associated fibroblasts in neoadjuvant setting for solid cancers
Critical Reviews in Oncology/HematologyTherapeutic approaches for cancer have become increasingly diverse in recent times. A comprehensive understanding of the tumor microenvironment (TME) holds great potential for enhancing the precision of tumor therapies. Neoadjuvant therapy offers the possibility of alleviating patient symptoms and improving overall quality of life. Additionally, it may
Yanan Gu +5 more
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