Results 121 to 130 of about 5,601,796 (250)

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Granzyme B PET Imaging Reveals Lgmn+ Macrophage‐Mediated Immune Evasion and Guides Immunotherapy in EGFR‐TKI‐Resistant NSCLC

Advanced Science, EarlyView.
Graphical illustration of 68Ga‐GZB PET/CT imaging reveals immune dynamics post‐EGFR‐TKI resistance in NSCLC; Lgmn+ macrophages‐derived Lgmn‐containing extracellular vesicles inhibit glycolysis, induce CD8+ T cell exhaustion, and targeting Lgmn restores immunotherapy sensitivity.
Dongliang Wang, Wenqin Luo, Qiufang Liu, Wenxuan Tang, Bin Zhu, Jiwei Chen, Qian Zhou, Shuang Tang, Xiaoping Xu, Shaoli Song   +9 more
wiley   +1 more source

Solubility enhancement of biperidine HCl by complexation with hydroxypropyl β-cyclodextrin

Journal of Applied Pharmaceutical Research, 2015
Oral route is the simplest and easiest way of drug administration, because of the greater stability, lesser bulk, and cheap cost of production, accurate dosage and easy process, solid oral dosage forms have several advantages over other dosage forms. All
Amit Dubey, Vikram Singh, Divya Juyal, Geet Rawat   +3 more
doaj  

Novel extended-release carbamazepine oral suspension: Formulation, evaluation and drug-release kinetic study

Pakistan Journal of Pharmaceutical Sciences
Common dosage forms have a number of drawbacks, including, but not exclusive, glitches in effectiveness, fluctuations in drug plasma concentration and poor patient’s compliance. Such problems can be overcome by formulation of the drug as modified-release
Harith Jameel Mahdi Alsammarraie, Menaa Abdulsalam Al-Abasi, Adnan Majeed Mohammad   +2 more
doaj   +1 more source

Caracterização físico-química de diferentes formas cristalinas e estudos de estabilidade de fluvastatina [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2012.Fluvastatina (FLV) é um fármaco pertencente à classe das estatinas, as quais têm como mecanismo de ação a ...
Borgmann, Silvia Helena Miollo
core  

Alternative manufacturing concepts for solid oral dosage forms from drug nanosuspensions using fluid dispensing and forced drying technology

, 2018
Flexible manufacturing technologies for solid oral dosage forms, which enable a continuous adjustability of the manufactured dose strength, are of interest for applications in personalized medicine and continuous manufacturing.
Michael Juhnke, Bastian Bonhoeffer, Kwade, Arno, Bonhoeffer, Bastian, Juhnke, Michael, Arno Kwade   +5 more
core   +1 more source

Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2

Advanced Science, EarlyView.
Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang, Chuanzan Zhou, Jiaoyan He, Pengpeng Huang, Rong Zhang, Huan Hu, Meng Jiao, Linyi Hu, Feng Liu, Xiaolong Qi, Xiang He, Yunkai Yang, Y Eugene Chinn, Dechao Feng, Dahong Zhang, Qi Zhang   +15 more
wiley   +1 more source

The Role of Functional Excipients in Solid Oral Dosage Forms to Overcome Poor Drug Dissolution and Bioavailability. [PDF]

Pharmaceutics, 2020
van der Merwe J, Steenekamp J, Steyn D, Hamman J.   +3 more
europepmc   +1 more source

ROS/pH‐Responsive Phenylboronic Acid–Chitosan Nanoparticles Improve Silymarin‐Mediated Hepatoprotection After Hepatectomy With Gut‐Liver Axis‐Associated Responses

Advanced Science, EarlyView.
Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong, Chaochao Luo, Zezheng Liu, Xinyan Zhang, Daixu Jia, Yang Sun, Zhaonan Zhang, Haoran Shi, Jianfang Wang, Hua Zhang   +9 more
wiley   +1 more source

The Design of Novel 3D-Printed, Moulded, and Oral Viscous Budesonide Formulations for Paediatrics: A Comparative Evaluation of Their Mucoadhesive Properties

Pharmaceutics
Background/Objectives: Paediatric eosinophilic oesophagitis (EoE) treatment is challenging due to the limited number of age-appropriate formulations. This study aims to develop and evaluate oral viscous suspensions and solid formulations of budesonide ...
María Magariños-Triviño, Eduardo Díaz-Torres, Javier Suárez-González, Ana Santoveña-Estévez, José B. Fariña   +4 more
doaj   +1 more source