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Recent progress in continuous manufacturing of oral solid dosage forms
International Journal of Pharmaceutics, 2020Continuous drug product manufacturing is slowly being implemented in the pharmaceutical industry. Although the benefits related to the quality and cost of continuous manufacturing are widely recognized, several challenges hampered the widespread introduction of continuous manufacturing of drug products.
V, Vanhoorne, C, Vervaet
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Sample Preparation for Solid Oral Dosage Forms
2011Development of extraction and sample preparation methods for solid oral dosage forms for potency and purity analysis can be challenging. Complete extraction of drug and impurities is required using reasonable extraction and sample preparation conditions, and the final prepared sample must be compatible with the analysis method.
Beverly Nickerson, Garry Scrivens
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Oral Conventional Solid Dosage Forms
2004This chapter gives the student a sense of the importance of the basic knowledge and scientific principles required to understand the manufacturing, formulation, use, and biopharmaceutical aspects of conventional solid dosage forms. It focuses on conventional solid oral dosage forms and divides into three sections: powder and granules, tablets, and ...
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Modified Release Solid Oral Dosage Forms
2019This chapter presents an extensive overview of the concepts of delayed-release, sustained-release, and pulsatile-release for drug delivery. Formulation approaches and delivery technologies are discussed in detail, along with the required performance testing for modified-release dosage forms. Abuse-deterrent technologies are also introduced.
Ashlee D. Brunaugh +2 more
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The Overview of Oral Solid Dosage Forms and Different Excipients Used for Solid Dosage Formulation
Global Academic Journal of Pharmacy and Drug Research, 2022When creating pharmaceutical dosage forms, the selection of excipients plays a significant role in the preformulation and formulation research. Excipients physical, mechanical, and chemical characteristics have a big impact on the final product and other formulation parameters like disintegration, dissolution, and shelf life.
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Immediate Drug Release from Solid Oral Dosage Forms
Journal of Pharmaceutical Sciences, 2005Fast drug release from solid dosage forms requires a very fast contact of the vast majority of the drug particles with the solvent; this, however, is particularly delayed in tablets and granulations. Starch and cellulose substances favor the matrix disintegration during the starting phase and the generation of the effective dissolution surface of the ...
Thomas, Schreiner +2 more
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Current Perspectives on the Dissolution Stability of Solid Oral Dosage Forms
Journal of Pharmaceutical Sciences, 1993Dissolution stability (i.e., retention of the dissolution characteristics of a solid oral dosage form from the time of manufacture up to its expiration date) is a critical parameter from the standpoint of quality control, regulatory compliance, and impact on the bioavailability of the product.
K S, Murthy, I, Ghebre-Sellassie
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Survival of Staphylococcus Aureus on Pharmaceutical Oral solid Dosage Forms
Journal of Pharmaceutical Sciences, 1973The relationship of temperature, relative humidity, size of inoculum, and duration of storage on survival of Staphylococcus aureus inoculated onto surfaces of 17 commercial tablets and one gelatin capsule was determined. The data were analyzed using a two-way factorial analysis of variance.
R F, Waterman +3 more
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Oral Controlled Release Solid Dosage Forms
2004The basic tenet in the design of oral controlled-release drug delivery systems is that the kinetics of drug release, rather than the kinetics of drug absorption, controls the availability of the drug. The developments in pharmaceutical dosage form design have been outlined to enable students to see the progressive nature of the efforts on delivery of ...
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