Results 21 to 30 of about 899,512 (307)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Magnetic micro-solid-phase extraction based on magnetite-MCM-41 with gas chromatography–mass spectrometry for the determination of antidepressant drugs in biological fluids [PDF]

, 2017
A new facile magnetic micro‐solid‐phase extraction coupled to gas chromatography and mass spectrometry detection was developed for the extraction and determination of selected antidepressant drugs in biological fluids using magnetite‐MCM‐41 as adsorbent.
Endud, Salasiah, Kamaruzaman, Sazlinda, Sanagi, Mohd Marsin, Wan Ibrahim, Wan Aini, Wan Ibrahim, Wan Nazihah, Yahaya, Noorfatimah   +5 more
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Two-phase wash to solve the ubiquitous contaminant-carryover problem in commercial nucleic-acid extraction kits [PDF]

, 2020
The success of fundamental and applied nucleic acid (NA) research depends on NA purity, but obtaining pure NAs from raw, unprocessed samples is challenging.
Ismagilov, Rustem F., Jue, Erik, Witters, Daan   +2 more
core  

Evaluation of Hungarian Wines for Resveratrol by Overpressured Layer Chromatography [PDF]

, 2013
A method, including solid phase extraction sample preparation, overpressured layer chromatographic separation and subsequent densitometric evaluation, was developed for measurement of total resveratrol (cis- and trans-isomers) content of wine. The amount
Airado-Rodriguez D., Arce L., Baptista J.A.B., Bavaresco L., Botz L., Boutegrabet L., Chen M., Creasy L.L., Dixon R.A., Dominguez C., Dugo G., Esna-Ashari M., Goldberg D.M., Goldberg D.M., Goldberg D.M., György Kátay, Hakimuddin F., Ingham J.L., Jaitz L., Jean-Denis J.B., Jeandet P., Jeandet P., Kerem Z., Király-Véghely Zs., Király-Véghely Zs., Klára Otta, Kolouchová-Hanzlíková I., Mahady G.B., Mark L., Martinez J., Mattivi F., McMurtrey K.D., Mercolini L., Mincsovics E., Mincsovics E., Mincsovics E., Nicolaou I.N., Paulo L., Pekec B., Peng Y.Y., Peres R.G., Pezet R., Pineiro Z., Porgali E., Quiros A.R.B., Renaud S., Rodler I., Rodríguez-Bernaldo de Quirós A., Romero-Perez A.I., Schmandke H., Siemann E.H., Siouffi A.M., Soleas G.J., Stark T., Tarola A.M., Tyihák E., Uenobe F., Vitrac X., Waddington E., Waterhouse A.L., Zotou A., Zsuzsa Király-Véghely, Ágnes Móricz   +62 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

SIDEROPHORES FOR SELECTIVE SOLID PHASE EXTRACTION OF STRATEGIC ELEMENTS [PDF]

, 2018
All over the world, industrial mining is leaving contaminated areas and dumps that, although being full of valuable metals, have high concentrations of toxic heavy metals that pollute the environment.
Bravo, Arturo, Humeres, Manuel-Jose, Levican, Gloria, Retamal-Morales, Gerardo, Schlömann, Michael, Schwabe, Ringo, Tischler, Dirk, Wiche, Oliver   +7 more
core  

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Solid Phase Extraction of Pesticides with Determination by Gas Chromatography [PDF]

, 2002
A simple, rapid, and effective method for the extraction of fifteen organochlorine and organophosphorus pesticides based on the use of solid phase Bond Elut C-18 cartridges was studied as an alternative method to those based on extraction with organic ...
Bhuiyan, Anwar A., Brotherton, Harry O.
core   +1 more source