Results 91 to 100 of about 4,672,322 (298)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The MAS NMR study of solid solutions based on the YAG crystal
Nukleonika, 2015 An 27Al magic angle spinning (MAS) nuclear magnetic resonance (NMR) study of nominally pure and Cr-doped yttrium-aluminum garnet (Y3Al5O12 and Y3Al5O12:Cr) crystals is reported.
Padlyak Bohdan V. +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
PHASE STRUCTURE OF Fe-Co-Ni NANOSYSTEMS: TEMPERATURE EFFECT
Вестник Кемеровского государственного университета, 2014 The processes occurring in biphase powders of Fe – Co – Ni at heating in vacuum are studied in the paper. Samples are synthesized by hydrazinehydrate reduction of metal salts in aqua solutions at highly alkaline medium. When drawing phase diagrams of the
K. A. Datiy +2 more
doaj
Metastability in solid solution growth
Journal of Crystal Growth, 2005 Abstract Crystallization of binary mixtures of 1,4-dichlorobenzene and 1,4-dibromobenzene is examined in an adiabatic calorimeter. First heated to 380 K under adiabatic conditions and thus transformed into a binary melt, the mixture was slowly cooled to 250 K.
Matovic, M. +2 more
openaire +4 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Regional Solutions coordinators
, 2017 "State resources are strategically aligned throughout Oregon to accomplish these goals [of community and economic development] though Regional Solutions Advisory Committees, Centers, and Teams...Coordination for these is provided by the Governor's Office"
core
GelsThe sol–gel coprecipitation method is highly efficient for synthesising a wide range of binary perovskite solid solutions (SSs), which have been under exhaustive study due to their semiconductor and catalytic properties.
Juan Carlos Rendón-Angeles +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source