Results 21 to 30 of about 649,583 (215)

A BAP1 synonymous mutation results in exon skipping, loss of function and worse patient prognosis

iScience, 2021
Summary: Synonymous mutations are generally disregarded by genomic analyses because they are considered non-pathogenic. We identified and characterized a somatic synonymous mutation in the epigenetic modifier and tumor suppressor BAP1, resulting in exon ...
Jennifer Niersch, Silvia Vega-Rubín-de-Celis, Anna Bazarna, Svenja Mergener, Verena Jendrossek, Jens T. Siveke, Samuel Peña-Llopis   +6 more
doaj   +1 more source

Esophageal Cancer and the Importance of Epidermal Growth Factor (EGFR) [PDF]

Reviews in Clinical Medicine, 2014
Esophageal squamous cell carcinoma (ESCC) is one of the most frequent malignancies, worldwide. It is important to find out what prognostic factors can facilitate diagnosis, optimize therapeutic decisions, and improve the survival of these patients ...
Kazem Anvari, Azam Anvari, Mehdi Silanian Toosi   +2 more
doaj   +3 more sources

MDM2 amplification and fusion gene ss18-ssx in a poorly differentiated synovial sarcoma: A rare but puzzling conjunction

Neoplasia: An International Journal for Oncology Research, 2020
The detection of specific alterations by genetic analyses has been included in the diagnostic criterions of the World Health Organization’s classification of soft tissues tumors since 2013.
Ilaria Di Mauro, Lénaïg Mescam-Mancini, Bruno Chetaille, Marick Lae, Gaelle Pierron, Bérengère Dadone-Montaudie, Audrey Bazin, Corinne Bouvier, Jean-François Michiels, Florence Pedeutour   +9 more
doaj   +1 more source

Fabrication and characterization of tretinoin-loaded nanofiber for topical skin delivery

Biomaterials Research, 2020
Background Tretinoin or all-trans retinoic acid is used in the treatment of acne vulgaris and photo-aging. This work aims to develop tretinoin-loaded nanofibers as a potential anti-acne patch and to investigate its physicochemical characteristics. Method
Saba Khoshbakht, Farzin Asghari-Sana, Anahita Fathi-Azarbayjani, Yaeghob Sharifi   +3 more
doaj   +1 more source

The Role of Targeted Therapy in Metastatic Renal Cell Carcinoma

The Scientific World Journal, 2007
Renal cell carcinoma (RCC) is a highly vascular tumor in which a growing understanding of disease biology has been translated into clinically active systemic therapies.
Jaya Unnithan, Brian I. Rini
doaj   +1 more source

Laboratory-Developed NGS Panel for Characterization of Advanced Colorectal Cancer, Real-World Data from a Tertiary Referral Centre

Diagnostics
Background/Objectives: Colorectal cancer (CRC) is one of the most frequently diagnosed malignancies and a leading cause of cancer-related mortality worldwide.
Floriana Jessica Di Paola, Giulia Calafato, Thais Maloberti, Laura Poppi, Giulia Ciccimarra, Sara Coluccelli, Viviana Sanza, Elisa Gruppioni, Annalisa Altimari, Antonio De Leo, Dario de Biase, Giovanni Tallini   +11 more
doaj   +1 more source

Evaluation of Microsatellite Instability via High-Resolution Melt Analysis in Colorectal Carcinomas

Journal of Molecular Pathology
Background/Objectives: Colorectal cancer (CRC) is the third leading cause of cancer death globally, with rising incidence. The immunohistochemistry (IHC) for mismatch repair (MMR) proteins is the first technique used in routine practice to evaluate an ...
Thais Maloberti, Sara Coluccelli, Viviana Sanza, Elisa Gruppioni, Annalisa Altimari, Stefano Zagnoni, Lidia Merlo, Antonietta D’Errico, Michelangelo Fiorentino, Daniela Turchetti, Sara Miccoli, Giovanni Tallini, Antonio De Leo, Dario de Biase   +13 more
doaj   +1 more source

Interactions of melatonin with various signaling pathways: implications for cancer therapy

Cancer Cell International, 2022
Melatonin is a neuro-hormone with conserved roles in evolution. Initially synthetized as an antioxidant molecule, it has gained prominence as a key molecule in the regulation of the circadian rhythm.
Ainaz Mihanfar, Bahman Yousefi, Bita Azizzadeh, Maryam Majidinia   +3 more
doaj   +1 more source

Improved Management of the Advanced Nonseminomatous Testis Cancer

Revista Brasileira de Cancerologia, 2023
With the VAB-6 program about 90% (54/59) of patients with stage III and bulky stage II disease achieved complete remission and eighty percent remain free of disease.
Davor Vugrin
doaj   +1 more source

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source