Results 141 to 150 of about 760,353 (358)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Natural Product Auraptene Targets SLC7A11 for Degradation and Induces Hepatocellular Carcinoma Ferroptosis

Antioxidants
The natural product auraptene can influence tumor cell proliferation and invasion, but its effect on hepatocellular carcinoma (HCC) cells is unknown.
Donglin Li, Yingping Li, Liangjie Chen, Chengchang Gao, Bolei Dai, Wenjia Yu, Haoying Yang, Junxiang Pi, Xueli Bian   +8 more
doaj   +1 more source

Understanding patterns of pathologic response following neoadjuvant immunotherapy for solid tumors

, 2018
Lynette M. Sholl
openalex   +1 more source

Supplementary Data from Results from a First-in-Human Phase I Study of Siremadlin (HDM201) in Patients with Advanced Wild-Type <i>TP53</i> Solid Tumors and Acute Leukemia

, 2023
Eytan M. Stein, Daniel J. DeAngelo, Jörg Chromik, Manik Chatterjee, Sebastian Bauer, Chia‐Chi Lin, Cristina Suárez, Filip De Vos, Neeltje Steeghs, Philippe A. Cassier, David Tai, Jean‐Jacques Kiladjian, Noboru Yamamoto, Rogier Mous, Jordi Esteve, Hironobu Minami, Stéphane Ferretti, Nelson Guerreiro, Christophe Meille, Rajkumar Radhakrishnan, Bernard Pereira, Luisa Mariconti, Ensar Halilovic, Claire Fabre, Cecilia Carpio   +24 more
openalex   +1 more source

Supplemental Figure 2 from AKT1^low Quiescent Cancer Cells Promote Solid Tumor Growth [PDF]

, 2023
Cleidson P. Alves, Ipsita Dey‐Guha, Sheheryar Kabraji, Albert C. Yeh, Nilesh P. Talele, Xavier Solé, Joeeta Chowdhury, Mari Mino–Kenudson, Massimo Loda, Dennis C. Sgroi, Anne‐Lise Børresen‐Dale, Hege G. Russnes, Kenneth N. Ross, Sridhar Ramaswamy   +13 more
openalex   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

GIGYF2: A Multifunctional Regulator at the Crossroads of Gene Expression, mRNA Surveillance, and Human Disease

Cells
GIGYF2 (Grb10-interacting GYF protein 2) functions as a versatile adaptor protein that regulates gene expression at various levels. At the transcriptional level, GIGYF2 facilitates VCP/p97-mediated extraction of ubiquitylated Rpb1 from stalled RNA ...
Chen-Shuo Zhao, Shu-Han Liu, Zheng-Yang Li, Jia-Yue Chen, Xiang-Yang Xiong   +4 more
doaj   +1 more source

Acute nonlymphocytic leukemia, preleukemia, and solid tumors following intensive chemotherapy of small cell carcinoma of the lung [PDF]

, 1985
J Pedersen-Bjergaard, K Osterlind, M Hansen, P Philip, Pedersen Ag, HH Hansen   +5 more
openalex   +1 more source

Supplementary Table from ARRY-382 in Combination with Pembrolizumab in Patients with Advanced Solid Tumors: Results from a Phase 1b/2 Study

, 2023
Melissa L. Johnson, Arkadiusz Z. Dudek, Ammar Sukari, Justin Call, Paul R. Kunk, Karl D. Lewis, Justin F. Gainor, John Sarantopoulos, Patrice Lee, Adele Golden, Allison S. Harney, S. Michael Rothenberg, Yuanyuan Zhang, Jonathan W. Goldman   +13 more
openalex   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source