Results 131 to 140 of about 247,537 (287)
TREX1, a predator for treating MSI‐H tumors?
Molecular Oncology, EarlyView.Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
Survey of agents and techniques applicable to the solidification of low-level radioactive wastes
, 1981 M. Fuhrmann +2 more
openalex +2 more sources
Dendritic growth and structure of undercooled nickel base alloys [PDF]
The principal objectives of this overall investigation are to: study means for obtaining high undercooling in levitation melted droplets, and study structures produced upon the solidification of these undercooled specimens.
Flemings, M. C., Shiohara, Y.
core +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Cailiao gongchengThe rapid advancement of high-tech technologies such as aerospace， electronic information， and biomedicine has required more demands on the properties of advanced ceramic materials. Single-characteristic structural or functional materials cannot meet the
TAN Xue +5 more
doaj +1 more source
Casting And Solidification Technology (CAST): Directional solidification phenomena in a metal model at reduced gravity [PDF]
The Casting and Solidification Technology (CAST) experiment will study the phenomena that occur during directional solidification of an alloy, e.g., constitutional supercooling, freckling, and dendrite coarsening. The reduced gravity environment of space
Mccay, M. H.
core +1 more source
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Journal of Materials Research and TechnologyIn this paper, the precipitate-free zones (PFZs) formed during creep testing in the peak-aged Mg-10Gd-0.4Zr casting alloy were carefully distinguished by different characteristics, the corresponding formation mechanisms and relationship with creep ...
He Qin +6 more
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Materials Research LettersA 22% variation in creep life was found at 950°C/245 MPa in single-crystal blades with different secondary orientations. In the experimental and simulation results, it was seen that the movement of {111} dislocations had caused the formation of the ...
Jiarun Qin +8 more
doaj +1 more source