Results 71 to 80 of about 676 (157)

Present and Future of Central Disorders of Hypersomnolence

Journal of Sleep Research, Volume 34, Issue 5, October 2025.
ABSTRACT Central disorders of hypersomnolence (CDH) are rare neurological conditions lumped by excessive daytime sleepiness (EDS) as primary complaint mostly arising at young age, including narcolepsy type 1 (NT1), narcolepsy type 2 (NT2), idiopathic hypersomnia (IH), and Kleine‐Levin syndrome (KLS). Advances in clinical and translational research have
Francesco Biscarini, Lucie Barateau, Fabio Pizza, Giuseppe Plazzi, Yves Dauvilliers   +4 more
wiley   +1 more source

A scoping review of clinical approach and personalized management of obstructive sleep apnea

Journal of Association of Pulmonologist of Tamil Nadu
Obstructive sleep apnea (OSA) is common yet frequently underdiagnosed. It not only impairs the sleep quality but also associated with multiple comorbidities. This review article aims at providing an update on the diagnosis and management of OSA through a
Nileena Namboodiripad Kakkattu Mana, Gomathi Dhamodaran, Ashok Kumar Balan, Vivekanand Vishnampettai Varadarajan, Nagarajan Ramakrishnan   +4 more
doaj   +1 more source

Treatment of narcolepsy and pregnancy: a review

Sleep Science and Practice
This is a chapter review of pregnancy state in patients with narcolepsy which aims to provide a review of literature regarding pregnancy in patients with narcolepsy, physiology of hormonal change during pregnancy on sleep, pharmacologic and non ...
Kullatham Kongpakpaisarn, Christine Won
doaj   +1 more source

Dose Determinations at Drug Approval Reviews: FDA‐Approved Drugs in Past 5 Years

Clinical Pharmacology &Therapeutics, Volume 117, Issue 6, Page 1743-1753, June 2025.
Drug dose appropriateness is one of the most discussed issues in regulatory reviews. We analyzed dose determinations during Food and Drug Administration (FDA) drug reviews to determine whether there were changes between the proposed and approved doses of new molecular entities (NMEs), including cases where postmarketing dose‐finding studies were ...
Sachiko Mita, Shunsuke Ono
wiley   +1 more source

SOLRIAMFETOL TITRATION AND ADMINISTRATION: DOSING AND TITRATION STRATEGIES IN PATIENTS WITH OSA STARTING SOLRIAMFETOL [PDF]

Chest, 2021
HARAMANDEEP SINGH, DANIELLE HYMAN, GREGORY PARKS, ABBY CHEN, CATHERINE FOLEY, DIANE ITO, MICHAEL THORPY   +6 more
openaire   +1 more source

pitolisant, a novel histamine-3 receptor competitive antagonist, and inverse agonist, in the treatment of excessive daytime sleepiness in adult patients with narcolepsy [PDF]

, 2022
Narcolepsy is a debilitating sleep disorder that presents with excessive daytime sleepiness (EDS) and cataplexy, which is a sudden paralysis of muscle tone triggered by strong emotions such as laughing.
Alvarez, Mark, Cornett, Elyse M, Hansen, Hannah, Kakazu, Juyeon, Kaye, Adam M, Kaye, Alan D, Okuampa, David, Sarfraz, Noeen   +7 more
core   +1 more source

Treating narcolepsy‐related nightmares with cognitive behavioural therapy and targeted lucidity reactivation: A pilot study

Journal of Sleep Research, Volume 34, Issue 3, June 2025.
Cognitive Behavioural Therapy for Nightmares, alone or in combination with targeted lucidity reactivation, significantly reduced nightmare frequency and severity, leading to remission of nightmare disorder in four of six participants. Sleep talking, NREM parasomnia symptoms, and self‐efficacy for managing symptoms also improved significantly.
Jennifer M. Mundt, Kristi E. Pruiksma, Karen R. Konkoly, Clair Casiello‐Robbins, Michael R. Nadorff, Rachel‐Clair Franklin, Sunaina Karanth, Nina Byskosh, Daniel J. Morris, S. Gabriela Torres‐Platas, Remington Mallett, Kiran Maski, Ken A. Paller   +12 more
wiley   +1 more source

The electroretinography to identify biomarkers of idiopathic hypersomnia and narcolepsy type 1

Journal of Sleep Research, Volume 34, Issue 1, February 2025.
Summary Hypersomnia spectrum disorders are underdiagnosed and poorly treated due to their heterogeneity and absence of biomarkers. The electroretinography has been proposed as a proxy of central dysfunction and has proved to be valuable to differentiate certain psychiatric disorders.
Héloïse Rach, Ulker Kilic‐Huck, Pierre A. Geoffroy, Tristan Bourcier, Sophie Braun, Henri Comtet, Elisabeth Ruppert, Laurence Hugueny, Marc Hebert, Eve Reynaud, Patrice Bourgin   +10 more
wiley   +1 more source

Is pitolisant safe for clinical use? A retrospective pharmacovigilance study focus on the post‐marketing safety

Pharmacology Research &Perspectives, Volume 12, Issue 1, February 2024.
Flow diagram of data collection and analysis of pitolisant‐associated adverse events. Abstract Pitolisant, a novel histamine H3‐receptor antagonist, holds significant promise for treating narcolepsy. However, a petition, which highlighted that pitolisant was associated with deaths during clinical trials, has propelled it into the spotlight of ...
Cheng Jiang, Jiancheng Qian, Xin Jiang, Shuohan Zhang, Junxian Zheng, Hongwei Wang   +5 more
wiley   +1 more source

Solriamfetol for Excessive Sleepiness in Obstructive Sleep Apnea (TONES 3). A Randomized Controlled Trial [PDF]

American Journal of Respiratory and Critical Care Medicine, 2019
Rationale: Primary treatment of obstructive sleep apnea can be accompanied by a persistence of excessive sleepiness despite adherence. Furthermore, effectiveness of sleep apnea treatment is limited by poor adherence. Currently available pharmacologic options for the treatment of sleepiness in this population are limited.
Schweitzer, Paula K, Rosenberg, Russell, Zammit, Gary K, Gotfried, Mark, Chen, Dan, Carter, Lawrence P, Wang, Hao, Lu, Yuan, Black, Jed, Malhotra, Atul, Strohl, Kingman P, Blackman, Adam, George, Charles, Shapiro, Colin, Shapiro, Colin, Benes, Heike, Fietze, Ingo, Mayer, Geert, Young, Peter, Lammers, Gert Jan, Ahmed, Mansoor, Ajayi, Akinyemi, Andry, James, Artal, Roy, Bastani, Bijan, Bogan, Richard, Corser, Bruce, Drake, Christopher, Emsellem, Helene, Erman, Milton, Feldman, Neil, Foldvary, Nancy, Gotfried, Mark, Hudson, John, Krahn, Lois, Lorch, Daniel, Malhotra, Atul, Maynard, James, Mignot, Emmanuel, Neeb, Michael, Ojile, Joseph, Perkins, Alvin Thomas, Rosenberg, Russell, Roy, Asim, Sahota, Pradeep, Sangal, R Bart, Schreiber, Andrew, Schweitzer, Paula, Steele, Ralph, Stern, Thomas, Stern, Thomas, Stolz, Sarah, Strohl, Kingman, Swick, Todd, Swick, Todd J, Thein, Stephen G, Thomas, Robert, Thorpy, Michael, Weaver, Terri, Wilks, Kerri, Winslow, David, Wylie, Paul, Zammit, Gary, Zee, Phyllis   +63 more
openaire   +5 more sources