Results 1 to 10 of about 1,093 (174)

Effects of Histamine H3 Receptor Antagonist/Inverse Agonist Pitolisant on Temporal Prediction, Spatial Switching, and Spontaneous Locomotion in Mice [PDF]

Neuropsychopharmacology Reports
Histamine receptors contribute to a wide range of brain functions, including arousal, motivation, attention, and memory, but their causal involvement in switching behavior remains insufficiently understood.
Shohei Kaneko, Kazuko Hayashi, Kota Yamada, Koji Toda   +3 more
doaj   +3 more sources

Pitolisant-associated mania – a case report [PDF]

BMC Neurology
Background Narcolepsy is a chronic neurological disorder treated with medications that promote wakefulness. Pitolisant, a histamine H3 receptor inverse agonist, is used to reduce excessive daytime sleepiness.
Maximilian Zoltek, Richard Ågren
doaj   +4 more sources

Is pitolisant safe for clinical use? A retrospective pharmacovigilance study focus on the post‐marketing safety

Pharmacology Research and Perspectives
Pitolisant, a novel histamine H3‐receptor antagonist, holds significant promise for treating narcolepsy. However, a petition, which highlighted that pitolisant was associated with deaths during clinical trials, has propelled it into the spotlight of ...
Cheng Jiang
exaly   +3 more sources

Pitolisant alleviates brain network dysfunction and cognitive deficits in a mouse model of Alzheimer’s disease [PDF]

Translational Psychiatry
Histamine H3 receptor (H3R) antagonists regulate histamine release that modulates neuronal activity and cognitive function. Although H3R is elevated in Alzheimer’s disease (AD) patients, whether H3R antagonists can rescue AD-associated neural impairments
Yang Zou, Linhan Yang, Jiahui Zhu, Jihua Fan, Hanrun Zheng, Xiang Liao, Zhiqi Yang, Kuan Zhang, Hongbo Jia, Arthur Konnerth, Yan-jiang Wang, Chunqing Zhang, Yun Zhang, Sunny C. Li, Xiaowei Chen   +14 more
doaj   +3 more sources

Pitolisant and Other Histamine-3 Receptor Antagonists—An Update on Therapeutic Potentials and Clinical Prospects

Medicines (Basel, Switzerland), 2020
Background: Besides its well-known role as a peripheral chemical mediator of immune, vascular, and cellular responses, histamine plays major roles in the central nervous system, particularly in the mediation of arousal and cognition-enhancement.
Pius Fasinu
exaly   +4 more sources

Pitolisant disrupts memory consolidation and hippocampal synaptic plasticity: Impaired excitability and long-term potentiation in the CA1 area [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): The histaminergic system plays a vital role in memory function, but the underlying cellular and circuit mechanisms remain poorly understood.
Siamak Beheshti, Adeleh Badiyifard, Zahra Badiei Darani, Mansour Azimzadeh, Alireza Halabian   +4 more
doaj   +2 more sources

Pitolisant Inhibits Alcohol Drinking and Improves Withdrawal Negative Affect Through Lateral Habenula Histaminergic Signaling in Mice. [PDF]

CNS Neurosci Ther
Pitolisant, an FDA‐approved H3R antagonist, counteracts the rewarding and sedative effects of ethanol, reduces alcohol intake, and alleviates the negative affect during withdrawal. This might occur via the antagonism of presynaptic autoreceptors and heteroreceptors H3Rs in the lateral habenula, thereby activating the H2R/p‐CREB/BDNF signaling and ...
Zhao Y, Fu Y, Liu T, Yang Z, Yang Z, Chen B, Zhou L, Yang J, Chen D, Han X, Tang Y, Ye JH, Miao CY, Fu R.   +13 more
europepmc   +2 more sources

Acute hypobaric hypoxia attenuates the anti-fatigue effects of pitolisant by downregulating the expression of organic cation transporter 1 and P-glycoprotein [PDF]

Frontiers in Pharmacology
ObjectiveThis study investigates the effects of acute hypobaric hypoxia (HH) on the anti-fatigue properties of pitolisant and explores the underlying mechanisms.
Gang Zhao, Yajuan Li, Mengyuan Liu, Mengyuan Liu, Wei Chang, Hui Shen, Junhui Xue, Junhui Xue, Junhui Xue, Fengzhou Liu, Fengzhou Liu   +10 more
doaj   +2 more sources

Histamine shapes the neurocomputational dynamics of human learning [PDF]

Nature Communications
Histamine was the first canonical monoamine identified in the mammalian brain, yet arguably remains the least understood in its mechanistic contributions to human behaviour.
Michael J. Colwell, Fin J. E. van Uum, Philip J. Cowen, Marieke A. G. Martens, Michael Browning, Helen C. Barron, Catherine J. Harmer, Susannah E. Murphy   +7 more
doaj   +2 more sources

Narcolepsy initially misdiagnosed as schizophrenia: A case report

Sleep Research
Sleep Research, Volume 3, Issue 2, Page 180-184, June 2026.
Feng Daoyi, Liu Xin, Xu Rui, He Lihua
doaj   +2 more sources