Results 41 to 50 of about 1,093 (174)

Estudio WAKE de vida real en pacientes con narcolepsia con cataplejía tratados con pitolisant no respondedores a tratamientos previos [PDF]

, 2022
INTRODUCTION. Type 1 narcolepsy is a disabling disease that requires continuous treatment, which is not always effective. Pitolisant is a new drug with a different mechanism of action that offers a new treatment option.
del Río-Villegas, Rafael, Tomás, Odile Romero-Santo, Romero-Santo Tomás, O, Cortés, María Yébenes, Gómez-Barrera, M, Gómez-Barrera, Manuel, Del Río-Villegas, R, Yébenes-Cortés, M, Martínez-Orozco, F J, Martínez-Orozco, Francisco J., Gaig-Ventura, Carles, Gaig-Ventura, C   +11 more
core   +1 more source

Pitolisant to Treat Excessive Daytime Sleepiness and Cataplexy in Adults with Narcolepsy: Rationale and Clinical Utility

Nature and Science of Sleep, 2020
Jay T Guevarra, Robert Hiensch, Andrew W Varga, David M Rapoport Division of Pulmonary, Critical Care, and Sleep Medicine, Mount Sinai Integrative Sleep Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USACorrespondence: Jay T ...
Guevarra JT, Hiensch R, Varga AW, Rapoport DM   +3 more
doaj  

Narcolepsy and rapid eye movement sleep

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Since the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive ...
Francesco Biscarini, Lucie Barateau, Fabio Pizza, Giuseppe Plazzi, Yves Dauvilliers   +4 more
wiley   +1 more source

Przekaźnictwo histaminergiczne w narkolepsji typu 1 – implikacje terapeutyczne

Aktualności Neurologiczne, 2018
Narkolepsja typu 1 (narkolepsja z katapleksją) jest chorobą objawiającą się nadmierną sennością dzienną, niekontrolowanym zasypianiem, epizodami katapleksji (nagłej utraty napięcia mięśniowego), halucynacjami hipnagogicznymi i hipnopompicznymi oraz ...
Mariusz Siemiński
doaj   +1 more source

cccDNA-Targeted Drug Screen Reveals a Class of Antihistamines as Suppressors of HBV Genome Levels

Biomolecules, 2023
Chronic infection with hepatitis B virus (HBV) is incurable, as the current therapeutics cannot eliminate its persistent genomic material, cccDNA. Screening systems for cccDNA-targeting therapeutics are unavailable, as low copies of cccDNA in vitro ...
Ee Chee Ren, Nicole Ziyi Zhuo, Zhi Yi Goh, Isabelle Bonne, Benoît Malleret, Hui Ling Ko   +5 more
doaj   +1 more source

Postmortem Evidence of CRH Neuron Reduction in Narcolepsy Without Cataplexy With Borderline Hypocretin‐1 Levels

Journal of Sleep Research, EarlyView.
ABSTRACT Narcolepsy is classified as type 1 (NT1) or type 2 (NT2) mainly according to hypocretin deficiency rather than cataplexy. While CRH neuron loss in the PVN has been described in NT1, it remains unclear whether similar changes occur in narcolepsy without cataplexy.
Ling Shan, Suzan Linssen, Rolf Fronczek, Lucie Barateau, Christelle Peyron, Yves Dauvilliers   +5 more
wiley   +1 more source

Substituted Purines as High-Affinity Histamine H₃ Receptor Ligands

Pharmaceuticals, 2022
Continuing with our program to obtain new histamine H3 receptor (H3R) ligands, in this work we present the synthesis, H3R affinity and in silico studies of a series of eight new synthetically accessible purine derivatives.
Christian Espinosa-Bustos, Luisa Leitzbach, Tito Añazco, María J. Silva, Andrea del Campo, Alejandro Castro-Alvarez, Holger Stark, Cristian O. Salas   +7 more
doaj   +1 more source

Neural Circuit Mechanisms of Disorders of Consciousness and Potential Therapeutic Targets of Brain Stimulation

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This review integrates three hierarchical frameworks—ascending reticular activating system (ARAS), mesocircuit hypothesis, and intrinsic connectivity networks (ICNs)—to update the neural mechanisms of disorders of consciousness (DoC). We highlight emerging evidence for glutamatergic ARAS pathways, a bidirectional GPi–GPe mesocircuit regulating ...
Yichen Zhou, Tianqing Cao, Sipeng Zhu, Qiheng He, Yitong Jia, Xiaoke Chai, Nan Wang, Yi Yang   +7 more
wiley   +1 more source

Increased Sensitivity of Mice Lacking Extrasynaptic δ-Containing GABAA Receptors to Histamine Receptor 3 Antagonists

Frontiers in Pharmacology, 2020
Histamine/gamma-aminobutyric acid (GABA) neurons of posterior hypothalamus send wide projections to many brain areas and participate in stabilizing the wake state.
Shamsiiat Abdurakhmanova, Milo Grotell, Jenna Kauhanen, Anni-Maija Linden, Esa R. Korpi, Pertti Panula   +5 more
doaj   +1 more source

Obstructive Sleep Apnea: Epidemiology, Pathophysiology, Complications, Diagnosis, Management, and Emerging Fibrosis‐Linked Remodeling

MedComm, Volume 7, Issue 8, August 2026.
Obstructive sleep apnea (OSA) is characterized by recurrent upper‐airway collapse, which generates key nocturnal stressors including intermittent hypoxia, sleep fragmentation, intrathoracic pressure stress, and sympathetic activation. These physiological disturbances converge on shared biological mechanisms, including oxidative stress, inflammation ...
Nhi Ho Thi Thuy, Thị Hằng Giang Phan, Ali Hussein Eid, Paola Maccioccu, Stefania Camboni, Gavino Casu, Anna Maria Posadino, Roberta Giordo, Gianfranco Pintus   +8 more
wiley   +1 more source