Results 21 to 30 of about 1,093 (174)

Comparative efficacy of new wake-promoting agents for narcolepsy-a network meta-analysis [PDF]

BMC Neurology
Background As a rare sleep disorder, narcolepsy is treated with various therapeutic options. This article systematically analyzes the efficacy and safety of novel approved wake-promoting drugs.
Zian Yan, Jiwei Li, Yixin Yu, Shenghan Qiu, Bing Wang, Jiyou Tang   +5 more
doaj   +2 more sources

Narcolepsy with co-occurring epilepsy: diagnostic pitfalls and management strategy [PDF]

Therapeutic Advances in Neurological Disorders
Narcolepsy and epilepsy are chronic neurological disorders that occasionally coexist. Overlapping symptoms, such as sudden loss of muscle tone and uncertainty regarding preservation of awareness, frequently complicate accurate diagnosis and ambiguity ...
Xinyan Zhang, Mengling Zha, Jiafeng Ren, Jiani Chen, Dong Zhou, Josemir W. Sander, Jinmei Li, Junying Zhou   +7 more
doaj   +2 more sources

Evaluation of pitolisant, sodium oxybate, solriamfetol, and modafinil for the management of narcolepsy: a retrospective analysis of the FAERS database [PDF]

Frontiers in Pharmacology
ObjectiveNarcolepsy, a rare neurological disorder believed to have an autoimmune etiology, necessitates lifelong management. This study aimed to provide evidence supporting the safety of pharmacological treatment for narcolepsy.MethodsFive-year data on ...
Xiaodan Zhou, Jia Chen, Bangtian Xu, Li Chen, Li Chen, Li Chen   +5 more
doaj   +2 more sources

Histamine H3 receptor inverse agonists/antagonists influence intra-regional cortical activity and inter-regional synchronization during resting state: an exploratory cortex-wide imaging study in mice [PDF]

Molecular Brain
The histaminergic system plays a key role in modulating learning and memory, wakefulness, and energy balance. Histamine H3 receptors constitutively inhibit the synthesis and release of histamine and other neurotransmitters. Therefore, H3 receptor inverse
Sentaro Kaita, Yoshikazu Morishita, Kenta Kobayashi, Hiroshi Nomura   +3 more
doaj   +2 more sources

Narcolepsy: a machine learning bibliometric analysis (1996–2024) [PDF]

Frontiers in Neurology
BackgroundNarcolepsy is a rare neurological cause of chronic sleepiness. This study aimed to better understand global narcolepsy through bibliometric analysis.MethodsArticles and reviews on narcolepsy were sourced from the Web of Science Core Collection.
Minheng Zhang, Xiaodong Hu, Haiyan Wu, Haixia Fan   +3 more
doaj   +2 more sources

The dual G9a inhibitor and histamine H3 receptor antagonist A-366 improves repetitive and social behaviors and attenuates neuroinflammation in BTBR T + tf/J mice [PDF]

Scientific Reports
Autism spectrum disorder (ASD) is a prevalent neurodevelopmental condition characterized by repetitive behaviors, impaired sociability, and persistent neuroinflammation.
Malak Hajar, Petrilla Jayaprakash, Holger Stark, Bassem Sadek   +3 more
doaj   +2 more sources

Migraine-inducing effects of pitolisant in women with migraine without aura: Protocol for a randomized, double-blind, placebo-controlled crossover trial

Cephalalgia Reports
Background Histamine and migraine have long been associated, with evidence showing that histamine infusion can trigger migraine-like attacks and that plasma histamine levels are often elevated in migraine patients, both during and between attacks ...
Isabella Helena Lange, Aida Maddahi, Lars Edvinsson, Lanfranco Pellesi   +3 more
doaj   +2 more sources

Pitolisant for Residual Excessive Daytime Sleepiness in OSA Patients Adhering to CPAP A Randomized Trial [PDF]

, 2021
BACKGROUND: Excessive daytime sleepiness (EDS) in individuals with OSA syndrome persisting despite good adherence to CPAP is a disabling condition. Pitolisant is a selective histamine H3-receptor antagonist with wake-promoting effects. RESEARCH QUESTION:
Pepin, Jean-Louis, Fietze, Ingo, Dauvilliers, Yves, Dokic, Dejan, Levy, Patrick, Verbraecken, Johan, Partinen, Markku, Lecomte, Jeanne-Marie, Tamisier, Renaud, Lecomte, Isabelle, Georgiev, Ognian, Belev, Georgi, Buyse, Bertien, Tiholov, Rumen, Schwartz, Jean-Charles, Attali, Valerie   +15 more
core   +3 more sources

The impact of pitolisant, an H3 receptor antagonist/inverse agonist, on perirhinal cortex activity in individual neuron and neuronal population levels

Scientific Reports, 2022
Histamine is a neurotransmitter that modulates neuronal activity and regulates various brain functions. Histamine H3 receptor (H3R) antagonists/inverse agonists enhance its release in most brain regions, including the cerebral cortex, which improves ...
Kyosuke Hirano, Yoshikazu Morishita, Masabumi Minami, Hiroshi Nomura   +3 more
doaj   +1 more source

Dual Targeting Ligands—Histamine H₃ Receptor Ligands with Monoamine Oxidase B Inhibitory Activity—In Vitro and In Vivo Evaluation

Pharmaceutics, 2022
The clinical symptoms of Parkinson’s disease (PD) appear when dopamine (DA) concentrations in the striatum drops to around 20%. Simultaneous inhibitory effects on histamine H3 receptor (H3R) and MAO B can increase DA levels in the brain.
Dorota Łażewska, Agata Siwek, Agnieszka Olejarz-Maciej, Agata Doroz-Płonka, Anna Wiktorowska-Owczarek, Marta Jóźwiak-Bębenista, David Reiner-Link, Annika Frank, Wioletta Sromek-Trzaskowska, Ewelina Honkisz-Orzechowska, Ewelina Królicka, Holger Stark, Marek Wieczorek, Waldemar Wagner, Katarzyna Kieć-Kononowicz, Anna Stasiak   +15 more
doaj   +1 more source