PLoS ONE, 2022 Metal-dependent histone deacetylases (HDACs) are essential epigenetic regulators; their molecular and pharmacological roles in medically critical diseases such as neuropsychiatric disorders, neurodegeneration, and cancer are being studied globally. HDAC2'
Anupam Raja +4 more
doaj +3 more sources
Neurologijos seminarai, 2020 In this review article, we present the treatment of narcolepsy since ancient times when patients experiencing the phenomenon of incubus (today understood as sleep paralysis with hypnagogic or hypnopompic hallucinations) were “cured” during the sessions ...
E. Sakalauskaitė-Juodeikienė +1 more
doaj +1 more source
Narcolepsy and Cataplexy – a practical approach to diagnosis and managing the impact of this chronic condition on children and their families [PDF]
, 2017 Narcolepsy is a relatively common neurological condition affecting the regulation of normal sleep/wake cycles leading to excessive daytime sleepiness (EDS).
Blackwell, J +3 more
core +1 more source
Sites of action of sleep and wake drugs: insights from model organisms [PDF]
, 2013 Small molecules have been used since antiquity to regulate our sleep. Despite the explosion of diverse drugs to treat problems of too much or too little sleep, the detailed mechanisms of action and especially the neuronal targets by which these compounds
Rihel, J, Schier, AF
core +1 more source
Investigation and management of residual sleepiness in CPAP-treated patients with obstructive sleep apnoea: the European view [PDF]
, 2022 Excessive daytime sleepiness (EDS) is a major symptom of obstructive sleep apnoea (OSA), defined as the inability to stay awake during the day. Its clinical descriptors remain elusive, and the pathogenesis is complex, with disorders such as insufficient
Asin, Jerryll +7 more
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The evolving small-molecule fluorescent-conjugate toolbox for Class A GPCRs [PDF]
, 2013 The past decade has witnessed fluorescently tagged drug molecules gaining significant attraction in their use as pharmacological tools with which to visualize and interrogate receptor targets at the single-cell level.
Hill, Stephen J. +2 more
core +2 more sources
Genetic Analysis of Histamine Signaling in Larval Zebrafish Sleep [PDF]
, 2017 Pharmacological studies in mammals and zebrafish suggest that histamine plays an important role in promoting arousal. However, genetic studies using rodents with disrupted histamine synthesis or signaling have revealed only subtle or no sleep/wake ...
Chen, Audrey +3 more
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Pitolisant protects mice chronically treated with corticosterone from some behavioral but not metabolic changes in corticosterone-induced depression model [PDF]
, 2020 Purpose: Histamine H3 receptor ligands may have antidepressant and anxiolytic effects. They can also compensate for metabolic disorders, which affect glucose or triglyceride levels.
Kieć-Kononowicz, Katarzyna +6 more
core +2 more sources
European guideline and expert statements on the management of narcolepsy in adults and children [PDF]
, 2021 Background and purpose: Narcolepsy is an uncommon hypothalamic disorder of presumed autoimmune origin that usually requires lifelong treatment. This paper aims to provide evidence-based guidelines for the management of narcolepsy in both adults and ...
Baldin, Elisa +17 more
core +11 more sources
Dysregulation of BDNF and PI3K/Akt signaling in the brain of female Wistar-Kyoto rats exposed to chronic mild stress [PDF]
, 2023 Background: The neurobiology underlying depression has not yet been fully identified, but is thought to result from molecular and cellular abnormalities that interact with genetic and environmental factors. Depression is twice as prevalent in women as in
Dronjak, Slađana +5 more
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