Results 71 to 80 of about 1,005 (173)

Utilizing quality by design methodology for liquid chromatography method development and validation in quantifying impurities in Pitolisant, a Histamine-3 (H3) receptor antagonist/inverse agonist

Results in Chemistry
We developed and validated a liquid chromatography technique to determine organic impurities of Pitolisant in Pitolisant film-coated tablets (4.45 mg and 17.8 mg), a medication used to treat excessive daytime drowsiness.
Jayaprakash Kanijam Raghupathi, Lova Gani Raju Bandaru, Kiran Kumar Madineni, Mastan Ali Syed, Sreekantha Babu Jonnalagadda, D. Ramachandran, Naresh Kumar Katari   +6 more
doaj   +1 more source

pitolisant, a novel histamine-3 receptor competitive antagonist, and inverse agonist, in the treatment of excessive daytime sleepiness in adult patients with narcolepsy

, 2022
Narcolepsy is a debilitating sleep disorder that presents with excessive daytime sleepiness (EDS) and cataplexy, which is a sudden paralysis of muscle tone triggered by strong emotions such as laughing.
Hansen, Hannah, Alvarez, Mark R, Kaye, Adam M., Okuampa, David, Sarfraz, Noeen, Kakazu, Juyeon, Cornett, Elyse M., Alvarez, Mark, Kaye, Alan D., Kaye, Alan David   +9 more
core   +1 more source

Pitolisant-supported bridging during drug holidays to deal with tolerance to modafinil in patients with narcolepsy

, 2023
Study objectives: Modafinil is a common treatment for excessive daytime sleepiness (EDS) in narcolepsy. The long-term use of modafinil can lead to tolerance with the loss of efficacy and the continuous increase of its dose. Pharmacological strategies to
Kallweit, Ulf, Apel, David, Groppa, Sergiu, Fleischer, Vinzenz, Winter, Yaroslav, Ellwardt, Erik, Lang, Christina   +6 more
core   +1 more source

The Histamine H3 Receptor Antagonist E159 Reverses Memory Deficits Induced by Dizocilpine in Passive Avoidance and Novel Object Recognition Paradigm in Rats

Frontiers in Pharmacology, 2017
The involvement of histamine H3 receptors (H3Rs) in memory is well known, and the potential of H3R antagonists in therapeutic management of neuropsychiatric diseases, e.g., Alzheimer disease (AD) is well established.
Alaa Alachkar, Dorota Łażewska, Katarzyna Kieć-Kononowicz, Bassem Sadek   +3 more
doaj   +1 more source

Treatment of narcolepsy and pregnancy: a review

Sleep Science and Practice
This is a chapter review of pregnancy state in patients with narcolepsy which aims to provide a review of literature regarding pregnancy in patients with narcolepsy, physiology of hormonal change during pregnancy on sleep, pharmacologic and non ...
Kullatham Kongpakpaisarn, Christine Won
doaj   +1 more source

Articles Safety and efficacy of pitolisant on cataplexy in patients with narcolepsy: a randomised, double-blind, placebo-controlled trial

, 2017
International audienceBACKGROUND:Histaminergic neurons are crucial to maintain wakefulness, but their role in cataplexy is unknown. We assessed the safety and efficacy of pitolisant, a histamine H3 receptor inverse agonist, for treatment of cataplexy in ...
Poverennova, Irina, Dauvilliers, Yves, Lecomte, Isabelle, HARMONY-CTP study group, Lecomte, Jeanne-Marie, Jankovic, Slavko, Lehert, Philippe, Krylov, Sergei, Schwartz, Jean-Charles, Szakacs, Zoltan, Mikhaylov, Vladimir, Sonka, Karel   +11 more
core   +1 more source

Recent advances in treatment for narcolepsy

Therapeutic Advances in Neurological Disorders, 2019
Narcolepsy type 1 (NT1) is a chronic orphan disorder, caused by the selective and irreversible loss of hypocretin/orexin (ORX) neurons, by a probable autoimmune process.
Lucie Barateau, Yves Dauvilliers
doaj   +1 more source

Comparative Efficacy and Safety of Multiple Wake-Promoting Agents for the Treatment of Excessive Daytime Sleepiness in Narcolepsy: A Network Meta-Analysis

Nature and Science of Sleep, 2023
Shuqin Zhan,1 Hui Ye,2 Ning Li,1 Yimeng Zhang,1 Yueyang Cheng,1 Yuanqing Wang,1,3 Shimin Hu,1 Yue Hou1 1Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, People’s Republic of China; 2Ignis Therapeutics (Shanghai ...
Zhan S, Ye H, Li N, Zhang Y, Cheng Y, Wang Y, Hu S, Hou Y   +7 more
doaj  

Pitolisant for the treatment of cataplexy in adults with narcolepsy [PDF]

Expert Opinion on Orphan Drugs, 2021
Gerard J. Meskill, Ulf Kallweit, Donna Zarycranski, Christian Caussé, Olivier Finance, Xavier Ligneau, Craig W. Davis   +6 more
openaire   +1 more source

First Report on Cationic Triphenylphosphonium Compounds as Mitochondriotropic H₃R Ligands with Antioxidant Properties

Antioxidants
Neurodegenerative diseases are a major public health problem due to the aging population and multifaceted pathology; therefore, the search for new therapeutic alternatives is of the utmost importance.
Tobias Werner, Tito Añazco, Paula Osses-Mendoza, Alejandro Castro-Álvarez, Cristian O. Salas, Raquel Bridi, Holger Stark, Christian Espinosa-Bustos   +7 more
doaj   +1 more source