Results 81 to 90 of about 1,093 (174)

Articles Safety and efficacy of pitolisant on cataplexy in patients with narcolepsy: a randomised, double-blind, placebo-controlled trial

, 2017
International audienceBACKGROUND:Histaminergic neurons are crucial to maintain wakefulness, but their role in cataplexy is unknown. We assessed the safety and efficacy of pitolisant, a histamine H3 receptor inverse agonist, for treatment of cataplexy in ...
Poverennova, Irina, Dauvilliers, Yves, Lecomte, Isabelle, HARMONY-CTP study group, Lecomte, Jeanne-Marie, Jankovic, Slavko, Lehert, Philippe, Krylov, Sergei, Schwartz, Jean-Charles, Szakacs, Zoltan, Mikhaylov, Vladimir, Sonka, Karel   +11 more
core   +1 more source

Eficacia y seguridad del Pitolisant en el tratamiento de la narcolepsia: revisión sistemática [PDF]

Título: Eficacia y seguridad del Pitolisant en el tratamiento de la narcolepsia: revisión sistemática. Objetivo: Determinar la eficacia y seguridad del pitolisant en el tratamiento de la narcolepsia.
Orbe Orbe, Willian Isael
core   +1 more source

First Report on Cationic Triphenylphosphonium Compounds as Mitochondriotropic H₃R Ligands with Antioxidant Properties

Antioxidants
Neurodegenerative diseases are a major public health problem due to the aging population and multifaceted pathology; therefore, the search for new therapeutic alternatives is of the utmost importance.
Tobias Werner, Tito Añazco, Paula Osses-Mendoza, Alejandro Castro-Álvarez, Cristian O. Salas, Raquel Bridi, Holger Stark, Christian Espinosa-Bustos   +7 more
doaj   +1 more source

Comorbidity of obstructive sleep apnea and narcolepsy: A challenging diagnosis and complex management

Sleep Medicine: X
Introduction: Narcolepsy and obstructive sleep apnea syndrome (OSA) are relevant causes of excessive daytime sleepiness (EDS); although different for etiopathogenesis and symptoms, differential diagnosis is sometimes difficult, and guidelines are lacking
Silvia Miano, Leila Kheirandish-Gozal, Marco De Pieri   +2 more
doaj   +1 more source

Histamine H₃ Receptor Isoforms: Insights from Alternative Splicing to Functional Complexity

Biomolecules
Alternative splicing significantly enhances the diversity of the G protein-coupled receptor (GPCR) family, including the histamine H3 receptor (H3R).
Meichun Gao, Jasper F. Ooms, Rob Leurs, Henry F. Vischer   +3 more
doaj   +1 more source

Novel Pitolisant-Derived Sulfonyl Compounds for Alzheimer Disease

International Journal of Molecular Sciences
Alzheimer’s disease (AD) is a complex and multifactorial neurodegenerative disorder characterized by cognitive decline, memory loss, behavioral changes, and other neurological symptoms. Considering the urgent need for new AD therapeutics, in the present study we designed, synthesized, and evaluated multitarget compounds structurally inspired by ...
Silvia Pérez-Silanes, Eva Martisova, Esther Moreno, Maite Solas, Daniel Plano, Carmen Sanmartin, María Javier Ramírez   +6 more
openaire   +3 more sources

Current and Emerging Therapies for Pediatric Sleep Disorders: A Narrative Review

Neurology and Therapy
Sleep disorders in children represent a significant public health concern with important implications for neurodevelopment, behavior, and overall health.
Lilliana Estrada Chaverri, Lourdes M. DelRosso, Fernando Alberto Ceballos Fuentes   +2 more
doaj   +1 more source

Wide implications of a trial on pitolisant for cataplexy [PDF]

The Lancet Neurology, 2017
openaire   +4 more sources

Long-term efficacy and safety of pitolisant for residual sleepiness due to OSA

: Background In people with OSA, excessive daytime sleepiness is a prominent symptom and can persist despite adherence to CPAP, the first-line therapy for OSA.
Tamisier, Renaud, P\ue9pin, Jean-Louis, Causs\ue9, Christian, Dauvilliers, Yves, Lecomte, Isabelle, Attali, Val\ue9rie, Verbraecken, Johan, Lehert, Philippe, L\ue9vy, Patrick, Hedner, Jan   +9 more
core  

Recent Advances and Emerging Pharmacotherapeutic Approaches for Central Hypersomnolence Disorders. [PDF]

Clin Pharmacol
Aribindi K, Shende TC, Albertson TE.
europepmc   +1 more source