Results 101 to 110 of about 1,005 (173)

Rational Design, Synthesis and Pharmacological Evaluation of Chalcones as Dual-Acting Compounds-Histamine H₃ Receptor Ligands and MAO-B Inhibitors. [PDF]

Int J Mol Sci
Łażewska D, Doroz-Płonka A, Kuder K, Siwek A, Wagner W, Karnafał-Ziembla J, Olejarz-Maciej A, Wolak M, Głuch-Lutwin M, Mordyl B, Osiecka O, Juszczak M, Woźniak K, Więcek M, Latacz G, Stasiak A.   +15 more
europepmc   +1 more source

Management of Central Disorders of Hypersomnolence in Pregnancy and Lactation. [PDF]

J Prim Care Community Health
Abideen ZU, Kolla BP, Bernard ME, Jegen DA, Furst JW, Mansukhani MP.   +5 more
europepmc   +1 more source

A Comprehensive Review of Current and Emerging Treatments for Narcolepsy Type 1. [PDF]

J Clin Med
Xu Q, Chen Y, Wang T, Zhu Q, Xu J, Zhang L.   +5 more
europepmc   +1 more source

Pharmacogenetic silencing histaminergic neurons results in reversible sleepiness and prevents wake-promoting effects of behavioral challenges and Pitolisant

International audienceBackground: Recent studies using opto- or pharmaco-genetics approach targeting histamine (HA) neurons of the tuberomammillary nucleus (TMN) show discrete or mild sleep-wake phenotypes, challenging therefore the role of HA neurons ...
Biolchini, Xavier, Lin, Jian‐sheng, Liu, Jiong, Wu, Sophie, Gervasoni, Damien, Shao, Yu-Feng   +5 more
core  

Antiseizure Medications that Did Not Reach the Epilepsy Market: An Assessment of Factors Contributing to Their Failed Clinical Development Over the Last Three Decades. [PDF]

Drugs
Bialer M, Perucca E.
europepmc   +1 more source

Development and validation of a method for quantitative determination of the genotoxic impurity diethyl sulfate in pitolisant hydrochloride <i>via</i> high-performance liquid chromatography. [PDF]

RSC Adv
Bhagwat S, Patil P, Pawar R, Shinde S, Amalnerkar D, Shinde D.   +5 more
europepmc   +1 more source

Comparative Efficacy and Safety of Multiple Wake-Promoting Agents for the Treatment of Residual Sleepiness in Obstructive Sleep Apnea Despite Continuous Positive Airway Pressure: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials. [PDF]

CNS Drugs
Tanayapong P, Tantrakul V, Liamsombut S, Siriyotha S, McKay G, Attia J, Thakkinstian A.   +6 more
europepmc   +1 more source

Obstructive Sleep Apnoea Treatments-Where Are We Now? [PDF]

Respirology
Luu S, Lee D, Yee BJ.
europepmc   +1 more source

Histamine H3 Receptor as a target for alcohol use disorder: challenging the predictability of animal models for clinical translation in drug development. [PDF]

Transl Psychiatry
Le Foll B, Naassila M, Jeanblanc J, Hendershot CS, Chavarria J, Calmels T, Krief S, Berrebi-Bertrand I, Uguen M, Perrin D, Ligneau X, Boileau I, Rusjan PM, Di Ciano P, Sabioni P, Capet M, Robert P, Finance O, Lecomte JM, Schwartz JC.   +19 more
europepmc   +1 more source

Trends and variation in issuance of high-cost narcolepsy drugs by NHS England organisations and regions from 2019 to 2022. [PDF]

J Sleep Res
van Someren F, Wiedemann M, Warren-Gash C, Sykorova M, Mistry H, Miller MA, Leschziner G, Nolte E, Belot A, Smith IE, Quinnell T, Eriksson SH, Strongman H.   +12 more
europepmc   +1 more source