New developments in the management of narcolepsy
Nature and Science of Sleep, 2017 Vivien C Abad, Christian Guilleminault Department of Psychiatry and Behavioral Sciences, Division of Sleep Medicine, Stanford University Outpatient Center, Redwood City, CA, USA Abstract: Narcolepsy is a life-long, underrecognized sleep disorder ...
Abad VC, Guilleminault C
doaj
Are Inverse Agonists of the Histamine H3 Receptor Effective in Reducing Excessive Daytime Sleepiness (EDS) in Individuals with Sleep Disorders? [PDF]
, 2018 OBJECTIVE: The objective of this systematic review is to determine whether or not “Are inverse agonists of the Histamine H3 receptor effective in reducing excessive daytime sleepiness (EDS) in individuals with sleep disorders?” DESIGN: Review of two ...
Peters, Kelly-Ann
core +1 more source
Dual target ligands with 4-tert-butylphenoxy scaffold as histamine H3 receptor antagonists and monoamine oxidase B inhibitors [PDF]
, 2020 Dual target ligands are a promising concept for the treatment of Parkinson’s disease (PD). A combination of monoamine oxidase B (MAO B) inhibition with histamine H3 receptor (H3R) antagonism could have positive effects on dopamine regulation.
Doroz-Płonka, Agata +10 more
core +1 more source
Advances in non-dopaminergic treatments for Parkinson's disease [PDF]
, 2014 Since the 1960's treatments for Parkinson's disease (PD) have traditionally been directed to restore or replace dopamine, with L-Dopa being the gold standard.
Stayte, S, Vissel, B
core +2 more sources
Drug‐induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann–Pick type C cells and mice [PDF]
, 2019 Most cells acquire cholesterol by endocytosis of circulating lowdensity lipoproteins (LDLs). After cholesteryl ester de-esterification in endosomes, free cholesterol is redistributed to intracellular membranes via unclear mechanisms.
Colaco, Alexandria +11 more
core +2 more sources
Frontiers in Pharmacology, 2017 The involvement of histamine H3 receptors (H3Rs) in memory is well known, and the potential of H3R antagonists in therapeutic management of neuropsychiatric diseases, e.g., Alzheimer disease (AD) is well established.
Alaa Alachkar +3 more
doaj +1 more source
Estudio WAKE de vida real en pacientes con narcolepsia con cataplejía tratados con pitolisant no respondedores a tratamientos previos [PDF]
, 2022 Rafael del Río Villegas +5 more
openalex +1 more source
Drugs affecting sleep and wakefulness: a review [PDF]
, 2018 It was in the second half of the twentieth century that Sleep Medicine was recognized as an immensely respected field of clinical research. As a result, past few decades have seen this field making some giant strides towards a better understanding of the
Amar, Avishek
core +2 more sources
Treatment of narcolepsy and pregnancy: a review
Sleep Science and PracticeThis is a chapter review of pregnancy state in patients with narcolepsy which aims to provide a review of literature regarding pregnancy in patients with narcolepsy, physiology of hormonal change during pregnancy on sleep, pharmacologic and non ...
Kullatham Kongpakpaisarn, Christine Won
doaj +1 more source
0623 Long-Term Evaluation of Safety and Efficacy of Pitolisant In Narcolepsy: Harmony III Study [PDF]
, 2018 Yves Dauvilliers +6 more
openalex +1 more source