cccDNA-Targeted Drug Screen Reveals a Class of Antihistamines as Suppressors of HBV Genome Levels
Biomolecules, 2023 Chronic infection with hepatitis B virus (HBV) is incurable, as the current therapeutics cannot eliminate its persistent genomic material, cccDNA. Screening systems for cccDNA-targeting therapeutics are unavailable, as low copies of cccDNA in vitro ...
Ee Chee Ren +5 more
doaj +1 more source
pitolisant, a novel histamine-3 receptor competitive antagonist, and inverse agonist, in the treatment of excessive daytime sleepiness in adult patients with narcolepsy [PDF]
, 2022 Narcolepsy is a debilitating sleep disorder that presents with excessive daytime sleepiness (EDS) and cataplexy, which is a sudden paralysis of muscle tone triggered by strong emotions such as laughing.
Alvarez, Mark +7 more
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Development of a conformational histamine H(3) receptor biosensor for the synchronous screening of agonists and inverse agonists [PDF]
, 2020 The histamine H(3) receptor (H(3)R) represents a highly attractive drug target for the treatment of various central nervous system disorders, but the discovery of novel H(3)R targeting compounds relies on the assessment of highly amplified intracellular ...
Leurs, R. +7 more
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Substituted Purines as High-Affinity Histamine H3 Receptor Ligands
Pharmaceuticals, 2022 Continuing with our program to obtain new histamine H3 receptor (H3R) ligands, in this work we present the synthesis, H3R affinity and in silico studies of a series of eight new synthetically accessible purine derivatives.
Christian Espinosa-Bustos +7 more
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Prader Willi locus Snord116 RNA regulates hypothalamic functions: sleep and temperature [PDF]
, 2020 Sleep is a complex behavior and it is hierarchically regulated involving several brain regions, neurotransmitters, and genes that co-operate in building modulatory mechanisms aimed at controlling and maintaining sleep.
FALAPPA, MATTEO
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Przekaźnictwo histaminergiczne w narkolepsji typu 1 – implikacje terapeutyczne
Aktualności Neurologiczne, 2018 Narkolepsja typu 1 (narkolepsja z katapleksją) jest chorobą objawiającą się nadmierną sennością dzienną, niekontrolowanym zasypianiem, epizodami katapleksji (nagłej utraty napięcia mięśniowego), halucynacjami hipnagogicznymi i hipnopompicznymi oraz ...
Mariusz Siemiński
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Nature and Science of Sleep, 2020 Jay T Guevarra, Robert Hiensch, Andrew W Varga, David M Rapoport Division of Pulmonary, Critical Care, and Sleep Medicine, Mount Sinai Integrative Sleep Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USACorrespondence: Jay T ...
Guevarra JT +3 more
doaj
Sleep Disorders in Adults with Prader-Willi Syndrome: Review of the Literature and Clinical Recommendations Based on the Experience of the French Reference Centre [PDF]
, 2022 Prader–Willi syndrome (PWS) is a rare, genetic, multisymptomatic, neurodevelopmental disease commonly associated with sleep alterations, including sleep-disordered breathing and central disorders of hypersomnolence.
Alice Bellicha +7 more
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Auxological and endocrine findings in narcolepsy type 1: seventeen-year follow-up from a pediatric endocrinology center [PDF]
, 2023 Introduction: Narcolepsy Type 1 (NT1) is a rare hypersomnia of central origin linked to hypocretin deficiency, most frequently arising at pediatric age. NT1 could be associated with endocrine comorbidities involving the neuroendocrine axis, predominantly
Assirelli V. +7 more
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Anti‐Obesity Pharmacotherapy and Emerging Multimodal Interventions for Obstructive Sleep Apnea
Chronic Diseases and Translational Medicine, EarlyView.Cellular and molecular mechanisms of obesity‐related obstructive sleep apnea (OSA). ADMA: asymmetric dimethyrarginine, NLRP3: nucleotide‐binding domain, leucine‐rich repeat family, Pyrin domain containing 3, TLR: toll‐like receptors, IL‐1β: interleukin‐1β, IL‐6: interleukin‐6; LPS: lipopolysacharide, ROS: reactive oxygen species, TNF‐α.
Anish Preshy +3 more
wiley +1 more source