Results 111 to 120 of about 514,430 (322)

Detection rate for ESR1 mutations is higher in circulating‐tumor‐cell‐derived genomic DNA than in paired plasma cell‐free DNA samples as revealed by ddPCR

open access: yesMolecular Oncology, EarlyView.
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou   +11 more
wiley   +1 more source

Strictly ascending HNN extensions in soluble groups [PDF]

open access: yesarXiv, 2010
We show that there exist finitely generated soluble groups which are not LERF but which do not contain strictly ascending HNN extensions of a cyclic group. This solves Problem 16.2 in the Kourovka notebook. We further show that there is a finitely presented soluble group which is not LERF but which does not contain a strictly ascending HNN extension of
arxiv  

Atlas of mildly and highly insoluble matrisome driving liver fibrosis

open access: yesFrontiers in Pharmacology
The excessive deposition and cross-linking of core matrisome components typically result in abnormal remodeling of the extracellular matrix (ECM), leading to increased liver stiffness and worsening liver fibrosis.
Wen Zhang   +20 more
doaj   +1 more source

Robust acute myeloid leukemia engraftment in humanized scaffolds using injectable biomaterials and intravenous xenotransplantation

open access: yesMolecular Oncology, EarlyView.
Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa   +13 more
wiley   +1 more source

Chief factors covered by projectors of soluble Leibniz algebras [PDF]

open access: yesarXiv, 2011
Let F be a saturated formation of soluble Leibniz algebras. Let K be an F-projector and A/B a chief factor of the soluble Leibniz algebra L. It is well-known that if A/B is F-central, then K covers A/B. I prove the converse: if K covers A/B, then A/B is F-central.
arxiv  

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu   +7 more
wiley   +1 more source

Profinite groups with soluble centralisers [PDF]

open access: yesarXiv
We show that a profinite group, in which the centralisers of non-trivial elements are metabelian, is either virtually pro-$p$ or virtually soluble of derived length at most 4. We furthermore show that a prosoluble group, in which the centralisers of non-trivial elements are soluble of bounded derived length, is either soluble or virtually pro-$p$.
arxiv  

Molecular Interaction and Solubilization Efficiency of Neohesperidin in Ternary Systems with Hydroxypropyl-β-cyclodextrin and Meglumine

open access: yesFoods
The solubilization of poorly water-soluble natural bioactive compounds remains a significant challenge. This study aims to design a ternary inclusion system to enhance the solubility of the poorly water-soluble compound Neohesperidin (NH).
Na Xia, Yanquan Liu, Dan Gao, Siming Zhu
doaj   +1 more source

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