Results 121 to 130 of about 1,983,588 (386)

Effect of Chemical Grafting Parameters on the Manufacture of Functionalized PVOH Films Having Controlled Water Solubility

Frontiers in Chemistry, 2017
This study investigated the chemical grafting of a single-layer poly(vinyl alcohol) (PVOH) film. The effect of the grafting parameters (grafting time, grafting temperature, and concentration of fatty acid chloride) on the hydrophobicity of the film ...
Andreas Haas, Andreas Haas, Daniel Schlemmer, Uwe Grupa, Markus Schmid, Markus Schmid   +5 more
doaj   +1 more source

Determination of Solubility Parameters of Ibuprofen and Ibuprofen Lysinate

Molecules, 2015
In recent years there has been a growing interest in formulating solid dispersions, which purposes mainly include solubility enhancement, sustained drug release and taste masking.
Teja Kitak, A. Dumicic, O. Planinšek, R. Šibanc, S. Srčič   +4 more
semanticscholar   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Solubility and Specific Rotatory Power of Carbohydrates and Certain Organic Acids and Bases in Pyridine and Other Solvents [PDF]

, 1905
Joseph G. Holty
openalex   +1 more source

THE SOLUBILITY OF GASES IN LIQUIDS

, 1979
The solubility Data Project aims to make a comprehensive search of the literature for data on the solubility of gases, liquids and solids in liquids. Data of suitable accuracy are compiled into data sheets set out in a uniform format. The data for each system are evaluated and where data of sufficient accuracy are available values recommended and in ...
Young, C. L., Battino, Rubin, Clever, H. Lawrence   +2 more
openaire   +8 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Conjugated Linoleic Acid–Carboxymethyl Chitosan Polymeric Micelles to Improve the Solubility and Oral Bioavailability of Paclitaxel

Pharmaceutics
Oral delivery, the most common method of therapeutic administration, has two significant obstacles: drug solubility and permeability. The challenges of current oral medicine delivery are being tackled through an emerging method that uses structures ...
Iqra Mubeen, Ghulam Abbas, Shahid Shah, Abdullah A Assiri   +3 more
doaj   +1 more source

CXXVII.—Isolation and synthesis of p-hydroxyphenylethylamine, an active principle of ergot soluble in water [PDF]

, 1909
George Barger
openalex   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Design and characterization of glimepiride hydrotropic solid dispersion to enhance the solubility and dissolution

Journal of Applied Pharmaceutical Research
Background: Glimepiride lowers blood sugar levels in the body, and treats type 2 diabetes mellitus. But the main problem with the drug is its low aqueous solubility.
Devakamma Lakumalla, Neeraja Podichety, Ravikumar Maddali   +2 more
doaj   +1 more source