Results 51 to 60 of about 2,048,035 (343)

Solids Turn into Liquids—Liquid Eutectic Systems of Pharmaceutics to Improve Drug Solubility

Pharmaceuticals, 2022
The low solubility of active pharmaceutical ingredients (APIs) is a problem in pharmaceutical development. Several methodologies can be used to improve API solubility, including the use of eutectic systems in which one of the constituents is the API ...
Mafalda C. Sarraguça, Paulo R. S. Ribeiro, Cláudia Nunes, Catarina Leal Seabra   +3 more
doaj   +1 more source

Formulation and characterization of an apigenin-phospholipid phytosome (APLC) for improved solubility, in vivo bioavailability, and antioxidant potential [PDF]

, 2016
The apigenin-phospholipid phytosome (APLC) was developed to improve the aqueous solubility, dissolution, in vivo bioavailability, and antioxidant activity of apigenin.
Anand, Sridhar, Dave, Vivek S., Fegade, Harshal, Patin, Arun T., Pethe, Anil M., Telange, Darshan R.   +5 more
core   +2 more sources

Implementing Health‐Related Quality of Life Assessment in Pediatric Oncology: A Feasibility Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background There is growing interest in embedding health‐related quality of life (HRQoL) assessment and patient‐reported outcome measures (PROMs) within clinical cancer care. This study evaluated the feasibility, acceptability, and usability of implementing an electronic PROM (ePROM) platform to measure HRQoL in children with cancer ...
Mikaela Doig, Sophie Jessop, Jordan R. Hansford, Hien Le, Matthew O'Connor, Peter Gorayski, Andrew Cunningham, Amanda Hutchinson, Victoria Bedford, Eva Bezak, Nayana Parange, Kelly Skelton, Timothy Price, Michala Short   +13 more
wiley   +1 more source

Dissolution Mechanism of YbOF in (LiF-CaF₂)_eut. Molten Salt

Molecules
The dissolution mechanism of YbOF in a fluoride-containing (LiF-CaF2)eut. molten salt is the basis for analyzing the structure of the resulting medium and optimizing the electrolytic preparation of rare-earth Yb alloys.
Linsheng Luo, Kailei Sun, Xu Wang
doaj   +1 more source

Bioavailability Enhancement Techniques for Poorly Aqueous Soluble Drugs and Therapeutics

Biomedicines, 2022
The low water solubility of pharmacoactive molecules limits their pharmacological potential, but the solubility parameter cannot compromise, and so different approaches are employed to enhance their bioavailability. Pharmaceutically active molecules with
Dixit V. Bhalani, Bhingaradiya Nutan, Avinash Kumar, Arvind K. Singh Chandel   +3 more
doaj   +1 more source

Rapid Response to Trametinib Combined With Chemotherapy for Infant BRAF‐Fused Chiasmatic Glioma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Infants, less than 1 year, with chiasmatic gliomas (ICG) present a major therapeutic challenge due to large tumor size, decreased vision, rapid progression, and poor response to vincristine/carboplatin chemotherapy. The majority have a BRAF fusion, which may respond to downstream MEK inhibitors but response time is slow. There are no safety or
Helen Toledano, Alexander Yelak, Walid Kaadan, Shlomo Caduri, Rivka Friedland, Orli Michaeli, Gad Dotan, Osnat Konen   +7 more
wiley   +1 more source

Assessment of Solubility and Sorption of Cention-N, Zirconomer, and Conventional GIC Restorative Materials Immersed in Different Beverages

Journal of Pharmacy and Bioallied Sciences
Objectives: The objective of this research was to assess the solubility and sorption values of various restorative materials immersed in different beverages.
Sanjit Kumar Sahoo, Naveen R. Reddy, Vaibhav Awinashe, Shahzad A. Shah, Swetha Vempalli, Noura Alessa, Prajwal Shetty, Vardarajula V. Ramaiah   +7 more
doaj   +1 more source

Morphology, Mechanical, and Water Barrier Properties of Carboxymethyl Rice Starch Films: Sodium Hydroxide Effect

Molecules, 2022
Carboxymethyl rice starch films were prepared from carboxymethyl rice starch (CMSr) treated with sodium hydroxide (NaOH) at 10–50% w/v. The objective of this research was to determine the effect of NaOH concentrations on morphology, mechanical properties,
Pornchai Rachtanapun, Sarinthip Thanakkasaranee, Rafael A. Auras, Nareekan Chaiwong, Kittisak Jantanasakulwong, Pensak Jantrawut, Yuthana Phimolsiripol, Phisit Seesuriyachan, Noppol Leksawasdi, Thanongsak Chaiyaso, Sarana Rose Somman, Warintorn Ruksiriwanich, Warinporn Klunklin, Alissara Reungsang, Thi Minh Phuong Ngo   +14 more
doaj   +1 more source

Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP

Nature Communications, 2018
Adenosine triphosphate (ATP) plays fundamental roles in cellular biochemistry and was recently discovered to function as a biological hydrotrope. Here, we use mass spectrometry to interrogate ATP-mediated regulation of protein thermal stability and ...
Sindhuja Sridharan, N. Kurzawa, Thilo Werner, Ina Günthner, D. Helm, W. Huber, M. Bantscheff, M. Savitski   +7 more
semanticscholar   +1 more source

Intraoperative Collection of Ascitic Fluid With Intra‐ or Postoperative Reinfusion in Ovarian Cancer: Safety and Feasibility of a Roller Pumping Method

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Patients with ovarian cancer often present with massive ascites, leading to significant protein loss during surgical procedures. Although cell‐free concentrated ascites reinfusion therapy (CART) is used in palliative settings to mitigate protein loss, its application in intraoperative settings remains unexplored.
Yutaka Yoneoka, Tsukuru Amano, Akimasa Takahashi, Mari Deguchi, Hiroyuki Yamanaka, Yuji Tanaka, Shunichiro Tsuji, Takashi Murakami   +7 more
wiley   +1 more source