Results 51 to 60 of about 1,117,205 (307)

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Investigation of possible solubility and dissolution advantages of cocrystals, I: Aqueous solubility and dissolution rates of ketoconazole and its cocrystals as functions of pH

ADMET and DMPK, 2019
Since there are conflicting reports in the literature on solubility and dissolution advantages of cocrystals over free forms, we systematically studied solubility and intrinsic dissolution rates of a weakly basic drug, ketoconazole, and its cocrystals ...
Jaydip M. Vasoya, Ankita V. Shah, Abu T.M. Serajuddin   +2 more
doaj   +1 more source

Effects of F, B2O3 and P2O5 on the solubility of water in haplogranite melts compared to natural silicate melts [PDF]

, 1993
The effects of F, B2O3 and P2O5 on the H2O solubility in a haplogranite liquid (36 wt. % SiO2, 39 wt. % NaAlSi3O8, 25 wt. % KAlSi3O8) have been determined at 0.5, 1, 2, and 3 kb and 800, 850, and 900°C.
Behrens, Harald, Dingwell, Donald B., Holtz, François   +2 more
core   +1 more source

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

Incompatibility of antimalarial drugs: challenges in formulating combination products for malaria

Drug Delivery
Lipophilic drugs require more advance formulation, especially if the intention is to make solutions or semisolid formulations. This also accounts for most antimalarial drugs. Although some of these antimalarial drugs are soluble in lipid vehicles, few of
Ellen K. G. Mhango, Benjamin R. Sveinbjornsson, Bergthora S. Snorradottir, Sveinbjorn Gizurarson   +3 more
doaj   +1 more source

ToxiM: A Toxicity Prediction Tool for Small Molecules Developed Using Machine Learning and Chemoinformatics Approaches

Frontiers in Pharmacology, 2017
The experimental methods for the prediction of molecular toxicity are tedious and time-consuming tasks. Thus, the computational approaches could be used to develop alternative methods for toxicity prediction.
Ashok K. Sharma, Gopal N. Srivastava, Ankita Roy, Vineet K. Sharma   +3 more
doaj   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Cyclodextrin-Based Nanotransporters as a Versatile Tool to Manage Oxidative Stress-Induced Lung Diseases

Antioxidants
Oxidative stress is one of the key elements in lung-related complications such as cystic fibrosis, acute lung injury, pulmonary hypertension, bronchopulmonary dysplasia, chronic airway diseases, lung cancer, COVID-19, and many others.
Supandeep Singh Hallan, Francesca Ferrara, Maddalena Sguizzato, Rita Cortesi   +3 more
doaj   +1 more source

Supersymmetry, shape invariance and the hypergeometric equation

, 2014
It has been shown earlier that the solubility of the Legendre and the associated Legendre equations can be understood as a consequence of an underlying supersymmetry and shape invariance. We have extended this result to the hypergeometric equation. Since
Das, Ashok K., Kalauni, Pushpa
core   +1 more source

Influence of pH, Temperature and Impurities on the Solubility of an Active Pharmaceutical Ingredient (API) [PDF]

, 2010
Solubility, which defines the liquid /solid equilibrium, is a key parameter to control a crystallization process. This work is focused on the effects of pH, temperature and impurities on the aqueous solubility of an Active Pharmaceutical Ingredient (API).
Autret, Jean Marie, Biscans, Béatrice, Estime, Nicolas, Teychené, Sébastien   +3 more
core   +1 more source