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Enhanced solubility of nanostructured paracetamol
Biomedical Physics & Engineering Express, 2016A thermodynamic top-down approach was used for quantitative prediction of the influence of size and shape of monoclinic paracetamol nanoparticles on their solubility in pure water. A thorough analysis of published experimental data on the bulk paracetamol solubility in water and its melting properties was performed and a temperature dependence of the ...
Jindřich Leitner, David Sedmidubský
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Solubility enhancement in supercritical solvents
Pure and Applied Chemistry, 1990Abstract
B. C.-Y. Lu, D. Zhang, W. Sheng
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Crystal Engineering for Enhanced Solubility and Bioavailability of Poorly Soluble Drugs
Current Pharmaceutical Design, 2018Background: Crystal engineering is dealing with the creation of new structures and new properties in drug molecules through inter-molecular interactions. Researchers of pharmaceutical sciences have used this knowledge to alter the structure of crystalline medications in order to remedy the problems of more than 40% of the new designed drugs which ...
Jaleh, Varshosaz +2 more
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Aprepitant: Review on Solubility Enhancement
Recent Advances in Drug Delivery and FormulationIntroduction: Substance P and its neurokinin (NK-1) receptors are upregulated in different pathophysiological conditions. Overexpression of the NK-1 receptor in cancer conditions has provided a promising pathway for cancer treatment. Clinically, Aprepitant (APT) is used as the only NK-1 antagonist in chemotherapy-induced nausea and vomiting (CINV ...
Lata Kothapalli +6 more
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Protein Design: From the Aspect of Water Solubility and Stability
Chemical Reviews, 2022Rui Qing, Shilei Hao, Eva Smorodina
exaly
Azilsartan Kamedoxomil: Solubility Enhancement Techniques
Biomaterials ConnectAzilsartan kamedoxomil (AZ) belongs to biopharmaceutical solubility class IV (BCS IV) that has low solubility and low permeability. Therefore, several techniques should be utilized to enhance its bioavailability, especially solubility enhancement.
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