Results 151 to 160 of about 87,397 (257)

Molecular mechanism of Xanthotoxol against gastric cancer: A comprehensive study integrating network pharmacology, computer simulations, and experimental validation

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Our study systematically explored the anti‐gastric cancer (GC) mechanism of Xanthotoxol (Xan), a natural active phytochemical, using an integrated strategy of network pharmacology, molecular simulation, and experimental validation. First, we identified 39 hub genes associated with gastric cancer using weighted gene co‐expression network analysis (WGCNA)
Yi Yang   +10 more
wiley   +1 more source

Boosting Charge Storage in Ferri/Ferrocyanide‐Based Alkaline Redox Flow Batteries

open access: yesAngewandte Chemie, EarlyView.
By modifying the solvation environment, cation engineering through Li+ substitution of traditional K+ or Na+ boosts the alkaline solubility of the ferri/ferrocyanide catholyte redox couple, providing a viable pathway to overcome the long‐standing challenge of energy density limitations for aqueous redox flow batteries (RBFs).
Mahla Sarfaraz Khabbaz   +6 more
wiley   +2 more sources

Remote Electrostatic Effect between Octahedral Ru/Ir‐Complexes and Aromatic Micelles to Improve Their Photofunctions in Water

open access: yesAngewandte Chemie, EarlyView.
The aqueous‐state encapsulation of cationic Ru(II)/Ir(III)‐complexes is efficiently demonstrated by anionic aromatic micelles via remote electrostatic interactions. The resulting host–guest composites exhibit enhanced metal‐complex‐based emission (∼3 to 10‐fold) and NIR emission through guest‐to‐guest FRET upon co‐encapsulation.
Rina Morooka   +2 more
wiley   +2 more sources

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

open access: yesAngewandte Chemie, EarlyView.
This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen   +3 more
wiley   +2 more sources

Polyproline: A Synthetic Polypeptide With Unique Properties

open access: yesAngewandte Chemie, EarlyView.
Poly‐L‐proline is a unique polypeptide distinguished by its well‐defined secondary structures and unusual thermal behavior. This mini review highlights recent advances in the synthesis of poly‐L‐proline by N‐carboxyanhydride (NCA) polymerization, the formation of structurally defined architectures and nanostructures, and emerging strategies that ...
Rosanna Le Scouarnec   +3 more
wiley   +2 more sources

Should I Stay or Should I Go—Leveraging an Overlooked Feature of Click‐to‐Release Chemistry for Affinity Labeling

open access: yesAngewandte Chemie, EarlyView.
Click‐to‐release (C2R) chemistry is redirected from payload liberation toward ligand‐directed covalent protein labeling through a transient dihydropyridazine methide (DHP‐methide). This concept opens the way to dual‐functional systems combining covalent target engagement with controlled effector release.
Dóra Kern   +9 more
wiley   +2 more sources

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