Results 201 to 210 of about 87,397 (257)

Solubilization and preformulation of carbendazim

International Journal of Pharmaceutics, 2002
The solubilization of carbendazim by pH in combination with cosolvents, surfactants or complexants was investigated. At pH 7 the total drug solubility is 6.11 +/- 0.45 microg/ml which increases by 1-7 fold with cosolvent, surfactant or complexant. However, at pH 2 the solubility increases by 250 times. Cosolvents have a negligible effect (50% increase)
Nina, Ni, Tapan, Sanghvi, Samuel, Yalkowsky   +2 more
openaire   +2 more sources

Solubilization of a Dendrimer into a Microemulsion

The Journal of Physical Chemistry B, 2010
The present work investigates, for the first time, a system comprising a dendrimer incorporated into the water core of water-in-oil (W/O) microemulsion (ME). A second generation (G-2) poly(propyleneimine) dendrimer (PPI) was solubilized into W/O ME composed of AOT (sodium bis(2-ethylhexyl)sulfosuccinate), heptane, and water.
Ido, Nir, Abraham, Aserin, Dima, Libster, Nissim, Garti   +3 more
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Cyclodextrins as pharmaceutical solubilizers

Advanced Drug Delivery Reviews, 2007
Cyclodextrins are useful functional excipients that have enjoyed widespread attention and use. The basis for this popularity from a pharmaceutical standpoint, is the ability of these materials to interact with poorly water-soluble drugs and drug candidates resulting in an increase in their apparent water solubility.
Marcus E, Brewster, Thorsteinn, Loftsson
openaire   +2 more sources

Solubilization of NSC-639829

International Journal of Pharmaceutics, 2001
Solubilization using pH combined with cosolvents, surfactants, and complexants are investigated for NSC-639829, an investigational anti-tumor agent. The intrinsic solubility of the drug is approximately 30 ng/ml and it has an ionizable dimethyl aniline group with an approximate base pK(a) of 5.
N, Jain, G, Yang, S E, Tabibi, S H, Yalkowsky   +3 more
openaire   +2 more sources

Hydrolysis of solubilized aspirin

Journal of Pharmaceutical Sciences, 1967
The hydrolysis of aspirin in buffered solutions of the nonionic surfactant, cetomacrogol, has been studied at 37° over the pH range 1 through 7. Cetomacrogol reduces the hydrolysis rate of unionized aspirin but not that of ionized aspirin. The reaction occurs mainly in the aqueous phase but at low pH the contribution of a hydrogen ion catalyzed ...
A G, Mitchell, J F, Broadhead
openaire   +2 more sources

Hydrolysis of solubilized esters

Journal of Pharmaceutical Sciences, 1967
The solubilizing ability of four nonionic surface-active agents is quantitatively compared. The critical micelle concentration (CMC) of the surface-active agents was evaluated from the solubility curves. The effect of the surface-active agents on the rate of hydrolysis of benzocaine and homatropine was investigated. At a concentration of surface-active
P B, Sheth, E L, Parrott
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Solubilization in nonionic microemulsions

Colloids and Surfaces, 1989
Solubilization of aqueous solutions in microemulsions containing nonionic surfactants has been investigated. The microemulsions are oil-continuous and free of any cosolvent or cosurfactant. The effects of electrolyte type and concentration, hydrocarbon chain length, and temperature on solubilization have been determined experimentally. Depending on the
S. Qutubuddin, J. M. Wiencek
openaire   +1 more source

Solubilization of the opiate receptor

Life Sciences, 1980
Abstract The opiate receptor is solubilized from rat neural membranes by treating the membranes with Triton X-100, followed by centrifugation. Removal of the Triton X-100 was accomplished with Bio-beads SM-2, and the resulting supernatant was capable of stereospecifically binding opiates at 10−13 moles/mg protein under saturating conditions ...
J M, Bidlack, L G, Abood
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Elastin purification and solubilization

2018
The functional form of elastin is a highly cross-linked polymer that organizes as sheets or fibers in the extracellular matrix. Purification of the mature protein is problematic because its insolubility precludes its isolation using standard wet-chemistry techniques.
Carmen M, Halabi, Robert P, Mecham
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Solubilization of inorganic calcium phosphates—Solubilization mechanisms

Soil Biology and Biochemistry, 1995
Abstract Two species [Penicillium aurantiogriseum and Pseudomonas sp. ( PI18 89 )] having high abilities in solubilizing inorganic phosphates (hydroxylapatite and brushite) were used to examine solubilization mechanisms. No direct contact between microorganisms and calcium phosphates (Ca-Ps) were necessary for effective solubilization.
P. Illmer, F. Schinner
openaire   +1 more source