Increased Levels of cAMP by the Calcium-Dependent Activation of Soluble Adenylyl Cyclase in Parkin-Mutant Fibroblasts [PDF]
Cells, 2019 Almost half of autosomal recessive early-onset parkinsonism has been associated with mutations in PARK2, coding for parkin, which plays an important role in mitochondria function and calcium homeostasis.
Paola Tanzarella +9 more
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The Role of Soluble Adenylyl Cyclase in the Regulation of Flagellar Motility in Ascidian Sperm [PDF]
Biomolecules, 2023 Flagellar motility in sperm is activated and regulated by factors related to the eggs at fertilization. In the ascidian Ciona intestinalis, a sulfated steroid called the SAAF (sperm activating and attracting factor) induces both sperm motility activation
Kogiku Shiba, Kazuo Inaba
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35336 Effect of Nuclear Soluble Adenylyl Cyclase (sAC) on Melanoma Treatment Response [PDF]
Journal of Clinical and Translational Science, 2021 IMPACT: Our data identify a novel candidate for combination strategy in melanoma treatment, and can inform clinicians in their decision-making process regarding therapeutic intervention for melanoma patients.
Jakyung Bang +4 more
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Comparative genomic analysis suggests that the sperm-specific sodium/proton exchanger and soluble adenylyl cyclase are key regulators of CatSper among the Metazoa [PDF]
Zoological Letters, 2019 Background CatSper is a sperm-specific calcium ion (Ca2+) channel, which regulates sperm flagellar beating by tuning cytoplasmic Ca2+ concentrations. Although this Ca2+ channel is essential for mammalian fertilization, recent bioinformatics analyses have
Francisco Romero, Takuya Nishigaki
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Erratum: Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential [PDF]
Frontiers in Physiology, 2022 Frontiers Production Office
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Strategies to safely target widely expressed soluble adenylyl cyclase for contraception [PDF]
Frontiers in Pharmacology, 2022 In humans, the prototypical second messenger cyclic AMP is produced by 10 adenylyl cyclase isoforms, which are divided into two classes. Nine isoforms are G protein coupled transmembrane adenylyl cyclases (tmACs; ADCY1-9) and the 10th is the bicarbonate ...
Jacob Ferreira +2 more
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Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential [PDF]
Frontiers in Physiology, 2022 In mammalian cells, 10 different adenylyl cyclases produce the ubiquitous second messenger, cyclic adenosine monophosphate (cAMP). Amongst these cAMP-generating enzymes, bicarbonate (HCO3−)-regulated soluble adenylyl cyclase (sAC; ADCY10) is uniquely ...
Thomas Rossetti +8 more
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On-demand male contraception via acute inhibition of soluble adenylyl cyclase [PDF]
Nature Communications, 2023 Half of all pregnancies are unintended; thus, existing family planning options are inadequate. This proof-of-concept study validates an on-demand contraception strategy for men, showing high effectiveness in quickly and temporarily reducing male ...
Melanie Balbach +11 more
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Piezo1 induces endothelial responses to shear stress via soluble adenylyl Cyclase-IP3R2 circuit [PDF]
iScience, 2023 Summary: Endothelial cells (ECs) continuously sense and adapt to changes in shear stress generated by blood flow. Here, we show that the activation of the mechanosensitive channel Piezo1 by defined shear forces induces Ca2+ entry into the endoplasmic ...
Dianicha Santana Nunez +8 more
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pH sensing via bicarbonate-regulated ‘soluble’ adenylyl cyclase (sAC) [PDF]
Frontiers in Physiology, 2013 Soluble adenylyl cyclase (sAC) is a source of the second messenger cyclic adenosine 3',5' monophosphate (cAMP). sAC is directly regulated by bicarbonate (HCO3-) ions. In living cells, HCO3- ions are in nearly instantaneous equilibrium with carbon
Nawreen eRahman +2 more
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